Summary
A gas chromatographic method with thermal conductivity detector (TCD) was developed for the determination of water in small amounts (2mg–20 mg) of solid chemicals. Quantification of water is carried out by using ethanol as an internal standard. The method shows good linearity in the range 0.1%–10% water. The precision as repeatability tested with a sample containing
0.5% water has a coefficient of variation of 5.3%. Comparison of the GC test results with another independent method (Karl-Fischer-titration) confirms the accuracy of the new method.
Easy handling, independence of the chemical structure of the test substance and the small amount of sample needed are the major advantages of this alternative method of determining the water content of solid chemicals.
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Nußbaum, R., Lischke, D., Paxmann, H. et al. Quantitative GC determination of water in small samples. Chromatographia 51, 119–121 (2000). https://doi.org/10.1007/BF02490705
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DOI: https://doi.org/10.1007/BF02490705