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Diastereo-enantioseparation of novel γ-lactamic derivatives on cellulose chiral stationary phases

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Summary

This paper describes the enantiorecognition of 1-methyl-3-hydroxy-5-aryl-2-pyrrolidinonic systems by high-performance liquid chromatography using two chiral derivatized cellulose stationary phases (CSPs) operated in the normal phase mode. According our results, the tris-(3,5-dimethylphenyl carbamate) cellulose, Chiralcel® OD, is more suitable than the tris-(4-methyl-phenylbenzoate), Chiralcel® OJ. On the first column, the resolution of the pyrrolidinonic compounds depends on the alcoholic modifier percentage.

A possible solute-stationary phase recognition mechanism is discussed. The temperature and mobile phase composition have been considered to explain the different contribution for the enantiomeric resolution.

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Authors and Affiliations

  1. Department of Pharmaco-Biological Sciences, University of Catanzaro “Magna Græcia”, Complesso “Nini Barbieri”, 88021, Roccelletta di Borgia, Catanzaro, Italy

    R. Ficarra, M. L. Calabrò & S. Alcaro

  2. Department of Medicinal Chemistry, University of Messina, Viale Annunziata, 98168, Messina, Italy

    S. Tommasini, S. Melardi & P. Ficarra

Authors
  1. R. Ficarra
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  2. M. L. Calabrò
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  3. S. Alcaro
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  4. S. Tommasini
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  5. S. Melardi
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  6. P. Ficarra
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Ficarra, R., Calabrò, M.L., Alcaro, S. et al. Diastereo-enantioseparation of novel γ-lactamic derivatives on cellulose chiral stationary phases. Chromatographia 51, 411–416 (2000). https://doi.org/10.1007/BF02490477

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  • DOI: https://doi.org/10.1007/BF02490477

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