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Enantioseparation of warfarin by capillary electrophoresis with UV and LIF detection using single and dual cyclodextrin type chiral selectors

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Summary

The enantioseparation of warfarin (WF) by capillary electrophoresis (CE) has been studied using various cyclodextrins (CD) such as native α,β and γ-CD, several neutral and randomly and selectively substituted charged CD derivatives. The enantiomer migration order of WF was determined with individual CDs. Various, CD combinations were used in order to enhance or diminish the separation factor in a designed way.

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Author notes

  1. B. Chankvetadze

    Present address: Molecular Recognition and Separation Science Laboratory, School of Chemistry, Tbilisi State University, Chavchavadze Ave 1, 380028, Tbilisi, Republic of Georgia

Authors and Affiliations

  1. Institute of Pharmaceutical Chemistry, University of Münster, Hittorfstr. 58-62, 48149, Münster, Germany

    B. Chankvetadze, N. Burjanadze & G. Blaschke

  2. Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, University of Liege, CHU, B 36, 4000, Liege 1, Belgium

    J. Crommen

Authors
  1. B. Chankvetadze
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  2. N. Burjanadze
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  3. J. Crommen
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  4. G. Blaschke
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Chankvetadze, B., Burjanadze, N., Crommen, J. et al. Enantioseparation of warfarin by capillary electrophoresis with UV and LIF detection using single and dual cyclodextrin type chiral selectors. Chromatographia 53 (Suppl 1), S296–S301 (2001). https://doi.org/10.1007/BF02490345

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  • DOI: https://doi.org/10.1007/BF02490345

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