Abstract
Three women less than 35 years old, who wanted to preserve their fertility, were conservatively treated with repeated endometrial curettage and medroxyprogesterone acetate (600mg/d) for endometrial carcinoma. Treatments were given once a month for 6 to 8 months. No patient had evidence of recurrence for at least 16 months after the treatment, and 1 patient subsequently delivered 2 full-term babies. This conservative treatment by endometrial curettage with progestogens may be considered for young patients with early endometrial lesions who wish to preserve their fertility.
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Masubuchi K, Nemoto H, Masubuchi S, Fujimoto I, Uchino S. Increasing incidence of endometrial carcinoma in Japan. Gynecol Oncol 1975;3:335–346.
Ito N, Niwa K, Horibe S, Nakanishi Y, Ito T, Sugiyama M, Kawazoe K, Morishita S, Tamaya T. Studies on clinicopathological studies on uterine carcinoma from 1984 to 1993 at the Department of Obstetrics and Gynecology, Gifu University School of Medicine, Acta Sch Med Univ Gifu (in Japanese, abstract in English) 1995;43:373–376.
Crissman JD, Azoury RS, Barnes AE, Schellhas HF. Endometrial carcinoma in women 40 years of age or younger. Obstet Gynecol 1981;57:699–704.
Gallup DG, Stock RJ. Adenocarcinoma of the endometrium in women 40 years of age and younger. Obstet Gynecol 1984; 64:417–420.
Niwa K, Yokoyama Y, Tanaka T, Murase T, Morishita S, Ito M, Ito N, Shimokawa K, Tamaya T. Successful pregnancy in a patient with endometrial carcinoma treated with medroxyprogesterone acetate. Arch Gynecol Obstet 1994;255:91–94.
Poulsen HE, Taylor CW. Histological typing of female genital tumours. In: Poulsen HE, Taylor CW (eds) International Histological Classification of Tumours, No. 13. Geneva: World Health Organization, 1975: 63–65.
Kottmeise HL. Annual report on the results of treatment in gynecological cancer. FIGO, Vol. 18, Stockholm, 1982.
Kistner RW. Treatment of hyperplasia and carcinoma in situ of the endometrium. Clin Obstet Gynecol 1982;25:63–74.
Kennedy BJ. Progestogens in the treatment of carcinoma of the endometrium. Surg Gynecol Obstet 1968;127:103–114.
Abeier VW, Kjrstad KE. Endometrial adenocarcinoma in Norway. A study of a total population. Cancer 1991;67:3093–3103.
Abeier VM, Vergote IB, Kjrstad KE, Tropé CG. Clear cell carcinoma: prognosis and metastatic pattern. Cancer 1996 78:1740–1747.
Nagaoka T, Onodera H, Matsushima Y, Todate A, Shibutani M, Ogasawara H, Maekawa A. Spontaneous uterine adenocarcinoma in aged rats and their relation to endocrine imbalance. J Cancer Res Clin Oncol 1990;116:523–628.
Niwa K, Tanaka T, Mori H, Mori H, Yokoyama Y, Furui T, Mori H, Tamaya T. Rapid induction of endometrial carcinoma in ICR mice treated with N-methyl-N-nitrosourea and estradiol. Jpn J Cancer Res 1991;82:1391–1396.
Gambrell DR. Role of hormones in the etiology and prevention of endometrial and breast cancer. Acta Obstet Gynecol Scand 1982;106 (suppl):37–46.
Gusberg SB. The individual at high risk for endometrial carcinoma. Am J Obstet Gynecol 1976;126:535–541.
Niwa K, Morishita S, Murase T, Ito N, Tanak T, Mori H, Tamaya T. Inhibitory effects of medroxyprogesterone acetate on mouse endometrial carcinogenesis. Jpn J Cancer Res 1995;86:724–729.
Ehrlich CE, Young PCM, Stehman FB, Scutton GP, Alford WM. Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium. Am J Obstet Gynecol 1988;158:796–807.
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Niwa, K., Morishita, S., Hashimoto, M. et al. Conservative therapy for endometrial carcinoma in young women treated with repeated curettage and progestogen. Int J Clin Oncol 2, 165–169 (1997). https://doi.org/10.1007/BF02490129
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DOI: https://doi.org/10.1007/BF02490129