Abstract
Deep-seated gliomas, including thalamic gliomas, have a poor prognosis because of difficulty of accessibility for surgery. In addition, an infiltrative pattern of the tumor is related to a poor prognosis. In this study, the infiltrative/invasive profile of the proliferating tumor cells of a right thalamic glioma was evaluated in an autopsied brain. A 71-year-old man died from extensive infiltration of a right thalamic glioma. The distribution of the proliferating tumor cells at the right thalamic tumor level was represented by the topographic map of MIB-1 labeling indices (LI) on the whole-brain coronal slice, and this map was analyzed with pathological findings and postmortem T2-weighted magnetic resonance imaging (MRI). The highest MIB-1 LI was 24% for the whole autopsy brain at the thalamic tumor level, whereas the MIB-1 LI was 21% for the biopsy sample of the right thalamic glioma. Because this patient survived only 9 months after diagnosis of the tumor as anaplastic astrocytoma, it was confirmed that 21% MIB-1 LI of the biopsy sample was relevant to his prognosis. The topographic map of MIB-1 LI showed that the proliferating tumor cells of the right thalamic glioma invaded the ventricular walls and the contralateral thalamus by the periventricular route, but there was no exophytic extension to the cortex. In conclusion, topographic analysis of the proliferative potential detected by MIB-1 immunostaining provides information on the growth pattern of human glioma.
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Steiger HJ, Gotz C, Schmid-Elsaesser R, et al (2000) Thalamic astrocytomas: surgical anatomy and results of a pilot series using maximum microsurgical removal. Acta Neurochir (Wien) 142: 1327–1337
Krouwer HG, Prados MD (1995) Infiltrative astrocytomas of the thalamus. J Neurosurg 82:548–557
Beks JW, Bouma GJ, Journee HL (1987) Tumors of the thalamic region. A retrospective study of 27 cases. Acta Neurochir (Wien) 85:125–127
Cheek WR, Taveras JM (1966) Thalamic tumors. J Neurosurg 24:505–513
Gerdes J, Lemke H, Baisch H, et al (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710–1715
Wakimoto H, Aoyagi M, Nakayama T, et al (1996) Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibodies in patients with supratentorial astrocytomas. Cancer 77:373–380
Pollack I, Cambell JW, Hamilton R, et al (1997) Proliferation index as a predictor of prognosis in malignant gliomas of childhood. Cancer 79:849–856
Cunningham JM, Kimmel DW, Scheithaner BW, et al (1997) Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value. J Neurosurg 86:121–130
Parkins CS, Darling JL, Gill SS, et al (1991) Cell proliferation in serial biopsies through human malignant brain tumors: measurement using Ki-67 antibody labelling. Br J Neurosurg 5:289–298
Amin MR, Kurosaki M, Watanabe T, et al (2000) A comparative study of MIB-1 staining indices of gliomas measured by NIH Image analysis program and conventional manual cell counting method. Neurol Res 22:495–500
Shin RW, Iwaki T, Kitamoto T, et al (1991) Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. Lab Invest 64:693–702
Scott EW, Mickle JP (1987) Pediatric diencephalic gliomas—a review of 18 cases. Pediatr Neurosci 13:225–232
Kelly PJ (1989) Stereotactic biopsy and resection of thalamic astrocytomas. Neurosurgery 25:185–195
Burger PC (1987) The anatomy of astrocytomas. Mayo Clin Proc 62:527–529
Kelly PJ, Daumas-Duport C, Kispert DB, et al (1987) Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms. J Neurosurg 66:865–874
Brant-Zawadzki M, Badami IP, Mills CM, et al (1984) Primary intracranial tumor imaging: a comparison of magnetic resonance and CT. Madiology 150:435–440
Atlas SW, Lavi E (1996) Intra-axial brain tumors. In: Atlas SW (ed.) Magnetic resonance imaging of the brain and spine, 2nd edn. Lippincott-Raven, Philadelphia, pp 315–422
Tovi M, Hartman M, Lilja A, et al (1994) MR imaging in cerebral gliomas: tissue component analysis in correlation with histopathology of whole-brain specimens. Acta Radiol 35:495–505
Johnson PC, Hunt SJ, Drayer BP (1989) Human cerebral gliomas: correlation of postmortem MR imaging and neuropathological findings. Radiology 170:211–217
Van den Hauwe L, Parizel PM, Martin JJ, et al (1995) Postmortem MRI of the brain with neuropathological correlation. Neuroradiology 37:343–349
Nagashima G, Suzuki R, Hokaku H, et al (1999) Graphic analysis of microscopic tumor cell infiltration, proliferative potential and vascular endothelial growth factor expression in an autopsy brain with glioblastoma. Surg Neurol 51:292–299
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Amin, M.R., Kamitani, H., Watanabe, T. et al. A topographic analysis of the proliferating tumor cells in an autopsied brain with infiltrative thalamic glioma. Brain Tumor Pathol 19, 5–10 (2002). https://doi.org/10.1007/BF02482449
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DOI: https://doi.org/10.1007/BF02482449