Abstract
A model of the processes occuring in the exchange of a drug between capillary plasma, extracellular space and intracellular space is developed. This leads to an interesting set of differential differences equations, one of which is an integrodifferential equation, another a partial differential equation. Under certain conditions, these may be simplified to a set of ordinary differential equations. The application of Laplace transform techniques to the solution of these equations is discussed.
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Bellman, R., Jacquez, J.A. & Kalaba, R. Some mathematical aspects of chemotherapy: I. One-organ models. Bulletin of Mathematical Biophysics 22, 181–198 (1960). https://doi.org/10.1007/BF02478005
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DOI: https://doi.org/10.1007/BF02478005