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Computer simulation of stem-cell kinetics

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Abstract

Computer simulation of the stem-cell system has been motivated by a desire to provide a device which may assist the experimenter in his development of complex research strategies in the rapidly developing investigative fields that relate to erythropoiesis and granulopoiesis. A simulation program, written in FORTRAN II for the IBM-7094, is being developed with the requirements of flexibility and broad applicability in mind. The biological model for which it originally was developed differs from those previously advanced by visualizing differentiation into the erythrocytic and granulocytic series as occurring during the post-mitotic phase of a stem cell's growth, the cell's susceptibility to erythropoietic and granulopoietic stimuli varying as its biochemical development unfolds. One might test this model by attempting to demonstrate an asymmetrical interference between erythropoietic and granulopoietic challenges to the stem-cell system.

A method for establishing an initial stable configuration of the model is presented. The simulation of the introduction of exogenous erythropoietic stimuli is described. And there is a brief description of the feedback mechanism employed to stabilize the size of the stem-cell population.

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Literature

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Authors and Affiliations

  1. Argonne Cancer Research Hospital, University of Chicago, Chicago, Ill.

    Carol M. Newton

  2. Committee on Mathematical Biology, University of Chicago, Chicago, Ill.

    Carol M. Newton

  3. Biological Sciences Computation Center, University of Chicago, Chicago, Ill.

    Carol M. Newton

Authors
  1. Carol M. Newton
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Additional information

Operated by the University of Chicago for the United States Atomic Energy Commission.

Supported by United States Public Health Service Grant FR00013, from the Division of Research Facilities and Resources, National Institutes of Health.

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Newton, C.M. Computer simulation of stem-cell kinetics. Bulletin of Mathematical Biophysics 27 (Suppl 1), 275–290 (1965). https://doi.org/10.1007/BF02477283

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  • DOI: https://doi.org/10.1007/BF02477283

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