Abstract
A general theory of the drying of frozen tissue is developed and applied to the measurement of the drying rate of frozen guinea pig liver. It is shown that for a given temperature of the subliming ice crystals the mininum drying time of a piece of guinea pig liver is greater than the minimum sublimation time of a piece of ice of the same size and shape by a factor of the order of one thousand. This fact has many implications in the design of freeze-dry apparatus which will be developed in a following paper.
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Aided by a grant from the Wallace C. and Clara A. Abbott Memorial Fund of the University of Chicago and from the Commonwealth Fund of New York.
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Stephenson, J.L. Theory of the vacuum drying of frozen tissues. Bulletin of Mathematical Biophysics 15, 411–429 (1953). https://doi.org/10.1007/BF02476434
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DOI: https://doi.org/10.1007/BF02476434