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The biological characteristics and chemosensitivity of anaplastic thyroid carcinoma transplanted into nude mice

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Abstract

Three xenografts established from three patients with anaplastic thyroid carcinoma were investigated for their biological characteristics and chemosensitivity. The histological and immunohistochemical findings of these tumors were almost the same as those of the original tumors. Although the growth rate of each xenograft was constant, the tumor doubling time varied from 4.8 per 9.0 days, and the labeling indexes, determined using bromodeoxyuridine pulse labeling, varied from 11.4 to 25.1 per cent. The chemosensitivity tests were performed according to the Battle Columbus Laboratories Protocol, with adriamycin, cyclophosphamide, cisplatin, mitomycin C and tegafur administered intraperitoneally to tumor-bearing nude mice in maximum tolerable doses. Tumors with slower growth rates tended to be sensitive to more drugs. Furthermore, cyclophosphamide showed antitumor effects against all the tumors tested. Althouth previous treatments of the original tumors may have affected the results, our results suggest that a more suitable chemotherapy for anaplastic thyroid carcinoma could be developed.

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Authors and Affiliations

  1. The Department of Surgery, Institute of Clinical Medicine, Universeity of Tsukuba, Tsukuba City, Ibaraki, Japan

    Akira Yoshida MD

  2. The Pathological Laboratory, University of Tsukuba, Tsukuba City, Ibaraki, Japan

    Masakatsu Fukazawa, Yuji Aiyoshi & Shugo Soeda

  3. Ito Hospital, Tokyo, Japan

    Kunihiko Ito

Authors
  1. Akira Yoshida MD
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  2. Masakatsu Fukazawa
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  3. Yuji Aiyoshi
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  4. Shugo Soeda
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  5. Kunihiko Ito
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Yoshida, A., Fukazawa, M., Aiyoshi, Y. et al. The biological characteristics and chemosensitivity of anaplastic thyroid carcinoma transplanted into nude mice. The Japanese Journal of Surgery 20, 690–695 (1990). https://doi.org/10.1007/BF02471034

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  • DOI: https://doi.org/10.1007/BF02471034

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