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A case of familial adenomatous polyposis complicated by thyroid carcinoma, carcinoma of the ampulla of vater and adrenocortical adenoma

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Abstract

A 63 year old female with familial adenomatous polyposis (FAP) complicated by carcinoma of the thyroid and ampulla of Vater and a nonfunctioning adrenocortical adenoma is reported herein. We reviewed 23 cases of duodenal or periampullary carcinoma, 10 cases of thyroid carcinoma and 4 cases of adrenal neoplasm presented in the Japanese literature. From studying these cases, we identified that FAP patients had a high risk of developing periampullary carcinoma and consequently, it is very important to periodically examine the ampulla of Vater. Thyroid carcinomas in patients with FAP were well differentiated carcinomas and occurred earlier than in the general population. The use of medical imaging equipment with mean that insidious abdominal tumors in cases of FAP will be detected more frequently in the future and as patients with FAP have a high risk of developing malignancies, surgery should be indicated for incidentally found adrenal tumors.

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References

  1. Iida M. Extra-colonic tumor-like lesions in familial polyposis of the colon and in Gardner's syndrome. Fukuoka Igaku Zasshi (Fukuoka Acta Med) 1978; 69: 169–200. (in Japanese with English Abst.)

    PubMed  CAS  Google Scholar 

  2. Obata M, Takagi K, Siooka M, Fujioka H, Tsuji T, Ohtsuka S, Tajima T, Tokimitsu N, Matsushita T, Kaneko I. A case of gastrointestinal polyposis associated with duodenal carcinoma. Nippon Naika Gakkai Zasshi (Jpn J Med) 1978; 67: 543. (in Japanese)

    Google Scholar 

  3. Kimura H, Nakamura T, Nakano G, Hoshi H, Nakano M. Development of early cancer of the ampulla of Vater and duodenal adenoma at seven years after total colectomy which was performed for the familial polyposis coli, report of a case. I to Cho (Stom Intest) 1982; 17: 983–987. (in Japanese with English Abst.)

    Google Scholar 

  4. Takano N, Akita Y, Karohji S. A case of adenomatosis coli with malignancy combined with carcinoma of the ampulla Vateri. Aomori Kenritsu Chuobyouin Ishi (Med J Aomori) 1982; 27: 384–389. (in Japanese)

    Google Scholar 

  5. Sugihara K, Muto T, Sawada T, Konishi F, Kamiya J, Morioka Y. Gardner's syndrome associated with duodenal cancer, report of a case. I to Cho (Stom Intest) 1982; 17: 977–982. (in Japanese with English Abst.)

    Google Scholar 

  6. Ogawa I, Takahara M, Kaji H, Takayasu T, Yamaoka Y, Sugitani A, Hikita N. A case of familial adenomatous polyposis with duodenal cancer. Proceedings, 19th annual Meeting, Chubu Surgical Society 1983; 100: (in Japanese)

  7. Yoshimi F, Koizumi S, Ishimaru M, Sunouchi H, Fujieda K, Satoh M, Mutoh T, Wada Y, Morioka Y. Gardner's syndrome initially diagnosed as periampullary carcinoma, report of a case. I to Cho (Stom Intest) 1984; 19: 1373–1378. (in Japanese with English Abst.)

    Google Scholar 

  8. Iida M, Yao T, Ito H, Watanabe H, Kouryo N, Shigematsu A, Iwashita A. Follow-up study of gastroduodenal lesions in familial adenomatosis coli. I to Cho (Stom Intest) 1984; 19: 621–638. (in Japanese with English Abst.)

    Google Scholar 

  9. Hishiki S, Baba S, Mizutani K, Morioka S, Nakamura S, Sakaguchi S. Cancer of the ampulla of Vater associated with familial polyposis coli, report of a case. I to Cho (Stom Intest) 1985; 20: 1027–1032. (in Japanese with English Abst.)

    Google Scholar 

  10. Egawa H, Horiuchi T, Shimozuma N, Asae M, Noguchi H, Hashimoto T, Tabuse Y, Tabuse K, Katsumi M, Ieda K, Tonoda S. Periampullary carcinoma associated with familial polyposis of the colon—report of a case and review of literature. Nippon Rinsho Geka Igakkai Zasshi (J Jpn Soc Clin Surg) 1985; 46: 1152–1158. (in Japanese with English Abst.)

    Google Scholar 

  11. Kajihara S, Kinoshita K, Kimura K, Ohyoshi M, Matsuoka S, Sumi S, Tada S. An experience of intestinal polyposis associated with duodenal and colonic cancer. Nippon ShokakiGeka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1986; 19: 557. (in Japanese)

    Google Scholar 

  12. Tada M, Kato S, Katagiri H, Okabe S, Hiranuma S, Shibata K, Sanada K, Okamoto K, Tonouchi M. A case of familial adenomatous polyposis detected after an operation for the ampulla of Vater. Ibarakiken Rinsho Igaku Zasshi (Ibaraki Med J) 1987; 23: 70. (in Japanese)

    Google Scholar 

  13. Aioi H, Utsunomiya G. Follow up study on familial adenomatosis coli—upper gastrointestinal lesions.— Gastroenterol Endosc 1987; 29: 2701–2703. (in Japanese and in English)

    Google Scholar 

  14. Masaki T, Muto T. Management of neoplastic lesions of the papilla Vater in patients with familial polyposis coli. Gastroenterol Endosc 1987; 29: 2704–2706. (in Japanese and in English)

    Google Scholar 

  15. Simoda T, Suwa T, Hirakata T, Sarashina H, Okui K. A case of familial adenomatosis coli associated with carcinoma of the ampulla Vateri. Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1987; 20: 2796–2799. (in Japanese)

    Google Scholar 

  16. Suzuki N, Nabeya K, Hanaoka T, Fukushima H, Kaku C, Kobayashi Y, Oguchi S, Fukuzumi N. A case report of adenomatosis coli associated with carcinoma of the papilla Vater and fundic gland polyposis. Nippon Shokaki geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1988; 21: 1150–1153. (in Japanese)

    Google Scholar 

  17. Yamanaka Y, Morita T, Inoue S, Hayakawa K, Konn M, Ono K. Adenomatosis coli associated with gastric and ampullary cancer; a case report. Nippon Daichou Koumon Byou Gakkai Zasshi (JJSCP) 1988; 41: 842–848. (in Japanese with English Abst.)

    Google Scholar 

  18. Hirokawa M, Manabe T, Hino K. Ampullary carcinoma in Gardner's syndrome: case report. Jpn J Clin Oncol 1988; 18: 43–50.

    PubMed  CAS  Google Scholar 

  19. Hohjyo M, Marugami Y, Kikuyama S, Takano M, Hashimoto T, Tomita T, Kojima M. A case of colon polyposis associated with carcinoma of the papilla Vateri. Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1989; 22: 2126–2129. (in Japanese)

    Google Scholar 

  20. Kataoka K, Kitagawa N, Toyoda K, Hashimoto Y, Takano N, Fujino R, Kuri F, Takahashi M. A case of familial adenomatous polyposis associated with early carcinoma of the ampulla of Vater and gastric cancer. Gastroenterol Endosc 1989; 31: 2238. (in Japanese)

    Google Scholar 

  21. Ogata H, Ohtsuka K, Tanaka K. A case of rectal cancer which presented an interesting metastasis. Bouei Eisei (Natl Def Med J) 1964; 11: 137–138. (in Japanese)

    Google Scholar 

  22. Takahashi S, Okuno Y, Nakamura A, Jinn S, Ono Y, Shinomura T, Kuwata Y, Seta K. Gardner's syndrome in association with thyroid carcinoma. Rinsho Geka (J Clin Surg) 1976; 31: 795–800. (in Japanese)

    Google Scholar 

  23. Iida M, Yao Y, Ohgushi H, Omae T, Ohsato K, Itoh H, Watanabe H, Mizutani T. Gastric lesions in familial adenomatosis of the colon; on their characteristics and follow up studies. I to Cho (Stom Intest) 1977; 12: 1365–1374. (in Japanese with English Abst.)

    Google Scholar 

  24. Ushio K, Abe S, Mitsushima T, Kimura T, Moriyama N, Takasugi T, Okazaki M, Matsue N, Sasagawa M, Yamada T, Oguro Y, Kodaira S, Hojo K, Koyama Y, Itabashi M, Hirota E, Ishikawa H. Gastric and duodenal lesions associated with familial polyposis coli. I to Cho (Stom Intest) 1977; 12: 1547–1557. (in Japanese with English Abst.)

    Google Scholar 

  25. Harada M, Murakami T, Shishido Y, Harada R, Itoh S, Konn M, Horimai T, Fujita H. Two cases of unusual extracolonic phenotypes accompanying familial polyposis of colon—one with papillary carcinoma of the thyroid and other with mesentric fibromatosis—. Nippon Shokaki Byou Gakkai Zasshi (Jpn J Gastroenterol) 1977; 74: 1567–1574. (in Japanese with English Abst.)

    CAS  Google Scholar 

  26. Okamura S, Kusugami K, Kurokawa S, Miwa M, Oka Y, Hattori T. A case of familial polyposis coli with interesting findings. Saishin Igaku 1979; 34: 2697–2700. (in Japanese)

    Google Scholar 

  27. Miura K, Yamaguchi A, Kawase K, Kondo S, Iwase K, Fukukei I, Ieda H. A case of adenomatous coli associated with carcinoma of the colon, ovary and thyroid gland and nodular hyperplasia of the adrenal cortex. Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1980; 13: 328–332. (in Japanese)

    Google Scholar 

  28. Masuyama K, Kawahara M, Mori T, Hayashi K, Tominaga K, Tanaka R. An atypical case of familial adenomatous polyposis with multiple thyroid cancers and colonic cancers. Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1986; 19: 1316. (in Japanese)

    Google Scholar 

  29. Furuya M, Tanaka T. A case of adrenal tumor in the young with colonic polyposis. Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol) 1989; 86: 1593. (in Japanese)

    Google Scholar 

  30. Cabot RC. Case records of the Massachusetts General Hospital case 21061. N Engl J Med 1935; 212: 263–268.

    Article  Google Scholar 

  31. Araki K, Nakashima A, Takahashi T, Harafuji I, Fukuhara T, Mimura H, Okajima K. A clinicopathologic study on carcinoma of papilla of Vater with special references to sex and age. Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 1980; 13: 1271–1278. (in Japanese)

    Google Scholar 

  32. Niwa M, Kato T, Saito Y, Ogoshi K. Diagnostic evaluation of cancer of the duodenal papilla. I to Cho (Stom Intest) 1988; 23: 1089–1094. (in Japanese with English Abst.)

    Google Scholar 

  33. Imaoka T, Nagasako R, Kuratsuka H, Nishimura S, Nagaoka S, Fukumoto S. Early carcinoma of the duodenum, report of a case and review of the literature in Japan. I to Cho (Stom Intest) 1988; 23: 1133–1137. (in Japanese with English Abst.)

    Google Scholar 

  34. Bitter DA, Ross DS. Incidentally discovered adrenal masses. Am J Surg 1989; 158: 159–161.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Research Center for Polyposis and Intestinal Disease, the Second Department of Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan

    Chihiro Ono, Takeo Iwama MD & Yoshio Mishima

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  1. Chihiro Ono
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  2. Takeo Iwama MD
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  3. Yoshio Mishima
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Ono, C., Iwama, T. & Mishima, Y. A case of familial adenomatous polyposis complicated by thyroid carcinoma, carcinoma of the ampulla of vater and adrenocortical adenoma. The Japanese Journal of Surgery 21, 234–240 (1991). https://doi.org/10.1007/BF02470915

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  • DOI: https://doi.org/10.1007/BF02470915

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