Abstract
Time-associated changes in the disappearance rate of indocyanine green from the blood (K·ICG) as an index of liver function, were studied. Blood was drawn 5 times at 3-minute intervals from 31 patients. Early, intermediate, and late K·ICG values were 0.087±0.040, 0.082±0.038, and 0.076±0.033 min−1, respectively, showing serial decreases. When blood was drawn 8 times at 2-minute intervals from 22 other patients, the means of the K·ICG values at 11 time points showed a nearly linear relationship (r=−0.986). These findings indicated that K·ICG is approxomated by a linear function of time, K(t)=−K′·t+K0. According to this function, K·ICG is considered to decrease by 1.96% every minute. The K·ICG value determined by the conventional method is, therefore, a mean disappearance rate of 15 minutes, and K0 is considered to reflect the initial reaction speed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Paumgartner G, Probst P, Kraines R, Leevy CM. Kinetics of indocyanine green removal from the blood. Ann NY Acad Sci 1970; 170: 134–147.
Mizumoto R. Application of ICG Rmax in surgery. Jpn Pharmacol Ther 1984; 12: 447–461.
Reemthma K, Hottinger GC, DeGraff AC, Creech O. Studies of hepatic function and blood flow using indocyanine green. Clin Res 1960; 8: 77.
Leevy CM, Smith F, Longueville J, Paumgartner G, Howard MM. Indocyanine green clearance as a test for hepatic function. Evaluation by dichromatic ear densitometry. JAMA 1967; 200: 236–240.
Yokosuka H, Nagayama K, Kumagai K, Fujisawa K, Shibata M, Aizawa T, Ogasawara H, Yano M, Narumiya N, Yoshino M, Ozawa Y, Horiguchi M. Changes in plasma concentration of indocyanine green over 15 minutes after injection. Jpn Pharmacol Ther 1982; 10: 95–101.
Koseki K, Nishihara T, Kasai M. Measurement of ICG Rmax by the plasma disappearance rate of ICG in earlier phase of its removal. Jpn Pharmacol Ther 1982; 10: 103–109.
Fox IJ, Brooker LGS, Heseltine DW, Essex HE, Wood EH. A tricarbocyanine dye for continuous recording of dilution curve in whole blood independent of variations in blood oxygen saturation. Proc Staff Meet Mayo Clin 1957; 32: 478–484.
Wheeler HO, Cranston WI, Meltzer JL. Hepatic uptake and biliary excretion of indocyanine green in the dog. Proc Soc. Exp Biol Med 1958; 99: 11–14.
Wheeler HO, Meltzer JI, Bradley SE. Biliary transport and the unanesthetized dog, in normal man, and in patients with hepatic disease. J Clin Invest 1960; 39: 1131–1144.
Katafuchi S, Idegami K, Morinaga H, Ichihara K, Sakamoto K, Yamane T, Ikei S, Mori K, Akagi M. Evaluation of ear densitometry on measuring the disappearance rate of indocyanine green. Jpn Pharmacol Ther 1984; 12: 329–333.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kumazawa, Ki., Kikuchi, T., Oishi, T. et al. Variations in the disappearance rate of indocyanine grenn. The Japanese Journal of Surgery 18, 1–6 (1988). https://doi.org/10.1007/BF02470839
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02470839