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A comparative study of experimental and human pancreatic carcinoma with special reference to histochemical findings

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Abstract

This study was undertaken in order to histochemically investigate the mucoid substances (acid mucopolysaccharide and sialic acid) in experimental and human pancreatic carcinoma. The degree of alcian blue staining in the ductal and interstitial portions of the pancreas increased, especially in hamster tubular adenocarcinoma which had been induced by N-nitrobis (2-hydroxypropyl) amine. The pancreatic carcinoma of the rats, induced by di-methyl benz (α) anthracene, was usually poorly differentiated carcinoma, in which alcian blue and toluidine blue staining was high in the interstitial portion when compared with that of the hamster pancreatic carcinoma, which was usually well differentiated. The rates of enzyme digestion of acid mucopolysaccharide and sialic acid showed more prominently in the rat pancreatic carcinoma than in the hamster pancreatic carcinoma. Mucoid substances in the ductal portion of human pancreatic carcinoma revealed properties similar to those of hamster pancreatic carcinoma whereas those in the interstitial portion were similar to those of rat pancreatic carcinoma. These results suggested that mucoid substances, especially acid mucopolysaccharide, both in experimental and human pancreatic carcinomas, may play an important role in tumor growth.

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References

  1. Yamagata T, Takebe T. Epidemiology of pancreatic cancer. Naika (Medicine) 1975; 36: 4–10. (in Japanese)

    Google Scholar 

  2. Books DC, Osteen RT, Gray EB. Evaluation of palliative procedures for pancreatic cancer. Am J Surg 1981; 141: 430–432.

    Article  Google Scholar 

  3. Ozzello L, Lasfargues EY, Murray MR. Growth-prompting activity of acid mucopolysaccharides on a strain of human mammary carcinoma cells. Cancer Res 1960; 20: 600–605.

    PubMed  CAS  Google Scholar 

  4. Takeuchi J. Growth-prompting effect of acid mucopolysaccharides on Ehrlich ascites tumor. Cancer Res 1966; 26: 797–802.

    PubMed  CAS  Google Scholar 

  5. Ozzello L, Speer FD. The mucopolysaccharides in the normal and diseased breast. Their distribution and significance. Am J Path 1958; 34: 993–1009.

    PubMed  CAS  Google Scholar 

  6. Majewska H, Majewsk C, Radziski J, Leja Z. Acid mucopolysaccharides in the ground substance of connective tissue in cancer of the skin. Cancer 1965; 18: 388–390.

    Article  PubMed  CAS  Google Scholar 

  7. Pour P, Kruger FW, Chem D, Althoff J, Cardesa A, Mohr U. Cancer of the pancreas induced in the Syrian Golden Hamster. Am J Path 1974; 76: 349–358.

    PubMed  CAS  Google Scholar 

  8. Dissen J, Mills LR, Mains DL, Black O, Webster PD. Experimental induction of pancreatic adenocarcinoma in rats. J Nat Cancer Inst 1975; 55: 857–864.

    Google Scholar 

  9. Galambos JT. Acid mucopolysaccharides and cirrhosis of the liver. Gastroenterology 1966; 51: 65–75.

    PubMed  CAS  Google Scholar 

  10. Moldow RE, Connelly RR. Epidemiology of pancreatic cancer in Connecticut. Gastroenterology 1968; 55: 677–686.

    PubMed  CAS  Google Scholar 

  11. Smith PE, Krementz ET, Reed RJ, Bufkin WJ. An analysis of 600 patients with carcinoma of the pancreas. Surg Gynecol Obstet 1967; 124: 1288–1290.

    PubMed  CAS  Google Scholar 

  12. Honjo I, Nakase A, Uchida K. Statistic review of surgical treatment of cancer of the pancreas in Japan. Journal of Jap Soc Cancer Their 1975; 10: 82–87. (in Japanese)

    CAS  Google Scholar 

  13. Edis AJ, Kiernan PD, Taylor WF. Attempted curative resection of ductal carcinoma of the pancreas. Review of Mayo Clinic Experience, 1951–1975, Mayo Clin Proc 1980; 55: 531–536.

    CAS  Google Scholar 

  14. Ishikawa O, Matsui Y, Aoki Y, Iwanaga T, Terasawa T, Wada A, Tateishi R, Akedo H. A histochemical study of the intracytoplasmic mucosubstances on chronic pancreatitis and pancreatic carcinoma. Jap J Gastro 1980; 77: 1635–1645. (in Japanese)

    CAS  Google Scholar 

  15. Sugimoto A. Histochemical observations on mucosubstances in the pancreatogenic and cholangiogenic carcinomas. Acta Histochem Cytochem 1979; 12: 629.

    Google Scholar 

  16. Moore MA, Takahashi M, Ito N, Bannasch P. Early lesions during pancreatic carcinogenesis induced in Syrian hamster by DHPN or DOPN. I. Histologic, histochemical and radioautographic findings. Carcinogenesis 1983; 4: 431–437.

    PubMed  CAS  Google Scholar 

  17. Klöppel G, Bommer G, Rückert K, Seifert G. Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis. Virchows Arch Path Anat and Histol 1980; 387: 221–233.

    Article  Google Scholar 

  18. Roberts PF, Burns J. A histochemical study of mucins in normal and neoplastic human pancreatic tissue. J Path 1972; 107: 87–95.

    Article  PubMed  CAS  Google Scholar 

  19. Hano K, Nishino Y. Pharmacological studies on the metabolism of mucopolysaccharides in tumor cells Gann 1965; 56: 49–58.

    PubMed  CAS  Google Scholar 

  20. Kimata K, Homma Y, Okayama M, Oguri K, Hozumi M, Suzuki S. Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential. Cancer Res 1983; 43: 1347–1354.

    PubMed  CAS  Google Scholar 

  21. Yamashita K. Histopathological studies of experimental pancreatic cancer produced by 7.12-Dimethylbenzanthracene (DMBA) in rats. J Jap Surg Soc 1980; 81: 317–329. (in Japanese)

    Google Scholar 

  22. Umeyama K, Satake K, Yamashita K, Yamamoto S, Kamino K, Sowa M. Pancreatic carcinoma in rats induced by 7.12-Dimethlbenzanthracene. Pathphysiology of carcinogenesis in digestive organs (Ed. by Faber et al). 1977; 385–396. Univ of Tokyo Press Tokyo.

    Google Scholar 

  23. Umeyama K, Satake K, Mukai R, Kato Y, Sowa M. Experimental pancreatic carcinoma. J Clinical Science 1983; 19: 806–813. (in Japanese)

    Google Scholar 

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Authors and Affiliations

  1. First Department of Surgery, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, 545, Osaka, Japan

    Michio Sowa MD, Yasuyuki Kato, Shigeru Yamamoto, Katsusuke Satake, Kenjin Kamino & Kaoru Umeyama

Authors
  1. Michio Sowa MD
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  2. Yasuyuki Kato
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  3. Shigeru Yamamoto
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  4. Katsusuke Satake
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  5. Kenjin Kamino
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  6. Kaoru Umeyama
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Sowa, M., Kato, Y., Yamamoto, S. et al. A comparative study of experimental and human pancreatic carcinoma with special reference to histochemical findings. The Japanese Journal of Surgery 17, 493–506 (1987). https://doi.org/10.1007/BF02470754

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  • DOI: https://doi.org/10.1007/BF02470754

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