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Splenic autotransplant and residual partial spleen: Prevention of septicemia

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Abstract

Postsplenectomy septicemia carries an ominous prognosis. Accompanying disseminated intravascular coagulation and adrenal hemorrhage result in a high mortality, despite aggressive treatment by antibiotics. The efficacy of prevention by in situ partial spleen and splenic auto-transplant were evaluated in Sprague-Dawley rats. All totally splenectomized rats died following intravenous challenge of liv pneumococcus. Both partial spleens and autotransplants gave substantial protection. The rats which succumbed to pneumococcal sepsis demonstrated massive fibrin thrombi in renal glomeruli and frank adrenal hemorrhage, strikingly similar to clinical observations.

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Author notes

  1. Anwar U. Haque

    Present address: University of Iowa Hospitals and Clinics, Iowa City, Iowa

  2. Peter Hudson

    Present address: Good Samaritan Hospital, Corvallis, Oregon

Authors and Affiliations

  1. Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas, USA

    Anwar U. Haque, Gary Wood & Norma J. Lindsey

  2. Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA

    Peter Hudson

Authors
  1. Anwar U. Haque
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  2. Peter Hudson
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  3. Gary Wood
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  4. Norma J. Lindsey
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Haque, A.U., Hudson, P., Wood, G. et al. Splenic autotransplant and residual partial spleen: Prevention of septicemia. The Japanese Journal of Surgery 14, 407–412 (1984). https://doi.org/10.1007/BF02469550

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  • DOI: https://doi.org/10.1007/BF02469550

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