Abstract
A new water-soluble preparation of terpene derivative, natural limonene with polyoxyethylene hydrogenated castor oil was introduced. This preparation made it possible to dissolve completely 1.412 to 3.250 gm human gallstones, such as pure cholesterol stone, cholesterol pigment-calcium stone in extraordinary short time, about 2 hoursin vitro. And remarkable dissolving effects were shown on 1.925 to 2.801 gm human cholesterol stone placed into the pig gallbladder after only two times of instillation of this preparationin vivo. Histological examination after this instillation was within normal limits on various organ of pig, such as the gallbladder, common bile duct, duodenum, small and large intestines, liver, kidneys, suprarenal glands and sternal-marrow. LD50 value of this new solvent was higher than 5g/kg, therefore it was revealed as non-toxic preparation. These results indicate that this new preparation can be applied clinically with safety especially to cholesterol stone. Moreover dissolving effect was shown even on bile pigment-calcium stone and fatty acid-calcium stone, however the dissolving velocity was not so high as that of cholesterol stone. When this new preparation will be used clinically, the conventional surgical procedures on residual gallstone can be improved.
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Hisatsugu, T., Igimi, H. & Nishimura, M. Dissolution of human gallstone. The Japanese Journal of Surgery 2, 62–72 (1972). https://doi.org/10.1007/BF02468933
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DOI: https://doi.org/10.1007/BF02468933