Abstract
After the surgical ligation of ileum, regional mesenteric vessels and nerves, a generalized stimulation of cell proliferation in the crypts and migration on the villi was demonstrated in rat. This increased cellular activity continued for up to 48 hours and decreased thereafter. The cellular response to surgical ligation differed from those mediated by anticancer agents in that the change of the cell renewal rate was generally less. Generation time of epithelial cells in the crypts and migration rate on the villi was found to be the same order of the magnitude in the duodenum, and ileum.
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References
Bertalanffy, F. D. and Nagy, K. P.: Mitotic activity and renewal rate of the epithelial cells of human duodenum, Acta Anat. 45: 362–370, 1961.
Leblond, C. P. and Messier B.: Renewal of chief cells and goblet cells in the small intestine as shown by radioautography after injection of thymidine-H3 into mice, Anat. Rec. 132: 247–259, 1958.
Lesher, S. W. and Bauman, J.: Cell proliferation in the intestinal epithelium, Recent result in cancer research, Springer Verlag, New York, 49–56, 1969.
Lesher, S. W., Fry, R. J. M. and Kohn, H. I.: Age and the generation time of the mouse duodenal epithelial cell, Exp. Cell Res. 24: 334–343, 1961.
Lipkin, M.: Cell replication in the gastrointestinal tract of man, Gastroenterology, 48: 616–624, 1965.
Lipkin, M., Sherlock, P. and Bell, B.: Cell proliferation kinetics in the gastrointestinal tract of man II. Cell renewal in stomach, ileum, colon, and rectum, Gastroenterology, 45: 721–729, 1963.
Lipkin, M and Deschner, E.: Comparative analysis of cell renewal in the gastrointestinal tract of newborn hamster. Exp. Cell Res. 49: 1–12, 1968.
Loran, M. R. and Crocker, T. T.: Population dynamics of intestinal epithelia in the rat two months after partial resection of the ileum, J. Cell Biol. 19: 285–291, 1963.
Margolis, S., Philips, F. S. and Sternberg, S. S.: The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis, Cancer Res. 31: 2037–2046, 1971.
Sherman, F. G. and Quastler, H.: DNA synthesis in irradiated intestinal epithelium, Exp. Cell Res. 19: 343–360, 1960.
Takemitsu, T., Kanemitsu, T., Kamei, H. and Kondo, T.: Dose schedules of chemotherapy related to the growth kinetics of tumor and host cells, Proceedigns of the Japanese Cancer Association, 31st Annual Meeting: 128, 1972 (in Japanese)
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Kamei, H., Watanabe, T., Takemitsu, T. et al. Cell renewal in experimentally obstructed small intestine in rat. The Japanese Journal of Surgery 3, 237–247 (1973). https://doi.org/10.1007/BF02468778
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DOI: https://doi.org/10.1007/BF02468778