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Effect of ovariectomy and androgen on the growth of mammary tumors induced by 7,12-dimethylbenz (α)-anthracene in rats

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Abstract

The effect of hormonal manipulation on the mammary tumor growth and on its histological changes were studied using DMBA-induced mammary tumor in rats. Ovariectomy resulted in regression of 83 per cent of the mammary tumors examined but most of the tumors regressed began to grow again after 7 to 8 weeks. The administration of androgen had inhibitory effect on the growth in 75 per cent of the tumors. The histology of the growing tumors before ovariectomy exhibited either a poorly differenciated or a tubulopapillary carcinoma. Histological features changed to atrophic cystic epithelium by ovariectomy and regrowing tumors following the post-ovariectomy remission tended to show reversion to primary features.

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Authors and Affiliations

  1. Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyoku, 602, Kyoto, Japan

    Toshio Takahashi, Takakazu Nakamura & Susumu Majima

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  1. Toshio Takahashi
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  2. Takakazu Nakamura
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  3. Susumu Majima
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Takahashi, T., Nakamura, T. & Majima, S. Effect of ovariectomy and androgen on the growth of mammary tumors induced by 7,12-dimethylbenz (α)-anthracene in rats. The Japanese Journal of Surgery 3, 229–236 (1973). https://doi.org/10.1007/BF02468777

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