Abstract
The weak carcinogen N-methyl-N'nitro-N-nitrosoguanidine injected 1 h before the potent carcinogen β-propiolactone decreased by half the incidence of induction and the number of tumors of the rumen in SWR mice. β-Propiolactone decreased the incidence of lung adenomas induced by weak carcinogen in these mice. Mutual effects of both compounds, which are inactivated in the body by a nonenzymatic route and requiring no metabolic activation for realization of their carcinogenic effects are probably realized through competition for targets.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 673–675, December, 1998
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Kaledin, V.I., Vasyunina, E.A., Morozkova, T.O. et al. A weak carcinogen protects from a potent carcinogen requiring no metabolic activation. Bull Exp Biol Med 126, 1242–1243 (1998). https://doi.org/10.1007/BF02447163
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DOI: https://doi.org/10.1007/BF02447163