Abstract
Heat shock is shown to lend a marked boost to the production of nitric oxide (NO), which attains the maximal level 1 hour after exposure and returns to the initial level after 24 hours. The generation of NO in all studied organs is completely blocked by Nω-nitro-L-arginine, an inhibitor of NO synthase, both in the control and after hyperthermia. Thus, heat shock markedly stimulates NO synthesis. This generalized effect may underlie the drop in the peripheral vascular tone that is characteristic of heat shock.
Similar content being viewed by others
References
A. F. Vanin, E. B. Manukhina, A. V. Lapshin, and F. Z. Meerson,Byull. Eksp. Biol. Med.,116, No. 8, 142–144 (1993).
V. D. Mikoyan, N. V. Voevodskaya, L. N. Kubrina,et al., Biokhimiya,59, No. 5, 732–738 (1994).
A. P. Shepelev,Vopr. Med. Khim.,22, No. 1, 47–51 (1976).
E. A. Carter, T. Derojaswalker, S. Tamur,et al., Biochem. J.,304, Pt. 1, 201–204 (1994).
C. V. Gisolfi, R. D. Matthes, K. C. Kregel, and R. Oppliger,J. Appl. Physiol.,70, 1821–1826 (1991).
A. V. Gourine, in:Thermal Balance in Health and Disease: Recent Basic Research and Clinical Progress, Eds. E. Zeisbergeret al., Birkhauser Verlag AG (1994), pp. 491–495.
D. M. Hall, G. R. Buettner, B. D. Matthes, and C. V. Gisolfi,J. Appl. Physiol.,77, No. 2, 548–533 (1994).
K. Hiki, Y. Yui, R. Hattori,et al., Jpn. J. Pharmacol.,56, 217–220 (1991).
A. J. Kielblock, N. B. Strydom, F. J. Burger,et al., Aviat. Space Environ. Med.,53, 171–178 (1982).
K. C. Kregel, P. T. Wall, and C. V. Gisolfi,J. Appl. Physiol.,64, 2582–2588 (1988).
A. Mülsch, B. Schray-Utz, P. I. Mordvintsev,et al., FEBS Lett.,321, No. 2–3, 215–218 (1993).
C. Nathan,FASEB J.,6, 3051–3064 (1992).
S. Shibolet, M. C. Lancaster, and Y. Danon.,Aviat. Space Environ. Med.,47, 280–301 (1976).
R. A. Star,Am. J. Med. Sci.,306, 348–358 (1993).
A. F. Vanin, P. I. Mordvintsev, and A. L. Kleshchev,Stud. Biophys.,107, 135–142 (1984).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 520–523, May, 1996
Rights and permissions
About this article
Cite this article
Manukhina, E.B., Malyshev, I.Y., Mikoyan, V.D. et al. Enhanced production of nitric oxide in rat organs in heat shock. Bull Exp Biol Med 121, 471–474 (1996). https://doi.org/10.1007/BF02446939
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02446939