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Effect of lamotrigin on the development of neurogenic pain syndrome in rats

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Analgesic activity of a new anticonvulsive agent lamotrigin was studied on the model of neurogenic pain syndrome produced in rats by penicillin applied to the dorsal surface of the spinal cord and by dissection of the sciatic nerve. Lamotrigin was shown to have a profound analgesic activity. It can be used as an efficient prophylactic agent for prevention of chronic pain syndromes by suppression of the generators of pathologically enhanced excitation in the nociceptive structures which are the pathophysiological basis of the chronic pain syndromes.

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Authors and Affiliations

  1. Laboratory of Physiology of Pain, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow

    M. L. Kukushkin, E. I. Danilova, V. N. Grafova, V. S. Smirnova & V. K. Reshetnyak

Authors
  1. M. L. Kukushkin
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  2. E. I. Danilova
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  3. V. N. Grafova
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  4. V. S. Smirnova
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  5. V. K. Reshetnyak
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 517–521, January, 1998.

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Kukushkin, M.L., Danilova, E.I., Grafova, V.N. et al. Effect of lamotrigin on the development of neurogenic pain syndrome in rats. Bull Exp Biol Med 125, 457–460 (1998). https://doi.org/10.1007/BF02445283

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  • DOI: https://doi.org/10.1007/BF02445283

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