Skip to main content
Log in

Clinically relevant computer model of cardiac rhythm and pacemaker/heart interaction

  • Computing and Data Processing
  • Published:
Medical and Biological Engineering and Computing Aims and scope Submit manuscript

Abstract

A computer simulation model of cardiac rhythm disturbances and of the heart/pacemaker interaction has been created and implemented on a NORD-100 minicomputer. The model incorporates important properties including cycle length dependence of the refractory periods of different parts of the heart and of the atrioventricular nodal conduction speed. Computational experiments produce an explicit timetable of polarisation changes, a simulated one-channel electrocardiographic record and a pacemaker marker channel. The simulation program is written infortran and uses discrete event simulation techniques. The heart is modelled using instances of nine simulation process prototypes. The paper presents and discusses several examples in the form of simulated electrocardiographic records and the results show that the model is clinically relevant. Included in the examples are the modelling of rhythm disturbances, pacemaker actions, pacing for tachycardia prophylaxis and atrioventricular nodal conduction disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ahnve, S. andVallin, H. (1982) Influence of heart rate and inhibition of autonomic tone on the QT interval.Circ.,65, 435–439.

    Google Scholar 

  • Conover, M. H. andZallis, E. G. (1976)Understanding electrocardiography: physiological and interpretive concepts. C.V. Mosby Co., St. Louis, Chap. 12, 118–126.

    Google Scholar 

  • Coumel, P. (1970) Management of paroxysmal tachycardia. InSymposium on cardiac arrhythmias.Sandoe, E., Flensted-Jensen, E. andOlesen, K. H. (Eds.), Ab Astra, Sweden, 783.

    Google Scholar 

  • Cuffin, B. N. andGeselowitz, D. B. (1977) Studies on the electrocardiogram using realistic cardiac and torso models.IEEE Trans.,BME 24, 242–252.

    Google Scholar 

  • Dassen, W., Brugada, P., den Dulk, K., Gorgels, A. andWellens, H. (1983) A mathematical model to study pacemaker related tachyarrhythmias, In:Computers in Cardiology,Ripley,K. L. (Ed.), IEEE Computer Society, Silver Springs, pp. 407–410.

    Google Scholar 

  • Dassen, W. R. M., van der Steld, A., van Braam, W., den Dulk, K., Gorgels, A. P. M., Brugada, P. andWellens, H. J. J. (1985) PACTOT: a reprogrammable software pacing system.Pacing Clin. Electrophys.,8, 574–578.

    Article  Google Scholar 

  • de Beer, E. L., Boom, H. B. K. andNaafs, B. (1977) The combined influence of the stimulus frequency on the vagal nerves and the atrial stimulus interval on the atrioventricular conduction time.Cardiovasc. Res.,11, 47–54.

    Google Scholar 

  • Dorveaux, L., Heddle, W., Jones, M. andTonkin, A. (1985) Examination of an exponential model of conduction through the human atrioventricular node.Pacing Clin. Electrophys.,8, 646–655.

    Article  Google Scholar 

  • Drouhard, J. P. andRoberge, F. A. (1982a) The simulation of repolarization events of the cardiac Purkinje fiber action potential.IEEE Trans.,BME-29, 481–493.

    Google Scholar 

  • Drouhard, J. P. andRoberge, F. A. (1982b) A simulation study of the ventricular myocardial action potential. ——Ibid.,BME-29, 494–502.

    Google Scholar 

  • Franta, W. R. (1977)The process view of simulation. Elsevier, New York.

    MATH  Google Scholar 

  • Furman, S. andFischer, J. D. (1982) Endless-loop tachycardia in an AV universal (DDD) pacemaker.Pacing Clin. Electrophys.,5, 486–489.

    Article  Google Scholar 

  • Gomes, J. A. C., Dhatt, M. S., Rubenson, D. S. andDamato, A. N. (1979) Electrophysiologic evidence for selective retrograde utilization of a specialized conducting system in atrioventricular nodal reentrant tachycardia.Am. J. Cardiol.,43, 687–698.

    Article  Google Scholar 

  • Gulrajani, R. M. andMailloux, G. E. (1983) A simulated study of the effects of torso inhomogeneities on electrocardiographic potentials, using realistic heart and torso models.Circ. Res.,52, 45–56.

    Google Scholar 

  • Hagen, C. T., Dassen, W. R. M., Bump, T. E. andArzbaecher, R. C. (1983) Arrhythmia simulation by computer modelling of cardiac conduction. InComputers in cardiology,Ripley,K. L. (Ed.), IEEE Computer Society, Silver Springs 217–220.

    Google Scholar 

  • Heethaar, R. M., van der Gon, D. J. J. andMeijler, F. L. (1973) Mathematical model of AV conduction in the rat heart.Cardiovasc. Res.,7, 105–114.

    Google Scholar 

  • Holley, L. andUther, J. (1985) A computer model of ventricular electrical activity and its application to ventricular arrhythmias.Vectors,14, 14–18.

    Google Scholar 

  • Kawataki, M., Kashima, T., Toda, H. andTanaka, H. (1984) Relation between QT interval and heart rate. Applications and limitations of Bazett's formula.J. Electrocardiol.,17, 371–376.

    Google Scholar 

  • Malík, M., Cochrane, T. andCamm, A. J. (1983) Computer simulation of the cardiac conduction system.Comput. Biomed. Res.,16, 454–468.

    Article  Google Scholar 

  • Malík, M. andCochrane, T. (1985) Shell computer model of cardiac electropotential changes.J. Biomed. Eng.,7, 266–274.

    Google Scholar 

  • Malík, M., Nathan, A. andCamm, A. J. (1985) Computer simulation of dual chamber pacemaker algorithms using a realistic heart model.Pacing Clin. Electrophys.,8, 579–588.

    Article  Google Scholar 

  • Malík, M. andCamm, A. J. (1986) Possible pathophysiology of torsade de pointes evaluated by a realistic heart computer model.Cardiovasc. Res.,20, 436–443.

    Article  Google Scholar 

  • Malík, M., Cochrane, T. andCamm, A. J. (1986a) Computer simulation of cardiac rhythm and artificial pacemakers using a ten element heart model.Comput. Biomed. Res.,19, 237–253.

    Article  Google Scholar 

  • Malík, M., Davies, D. W. andCamm, A. J. (1986b) Limiting factors in the use of DDD pacemakers to prevent junctional reentry: computer modeling experiments.Clin. Progr. Electrophys. Pac.,4, 137–146.

    Google Scholar 

  • Miller, W. T. andGeselowitz, D. B. (1978) Simulation studies of the electrocardiogram.Circ. Res.,43, 301–323.

    Google Scholar 

  • Nelson, C. V. andGeselowitz, D. B. (Eds.) (1976)The theoretical basis of electrocardiology. Oxford University Press, Oxford.

    Google Scholar 

  • Olson, W. H., McConnell, M. V., Sah, R. L., Beck, R. C. andSutton, R. (1985) Pacemaker diagnostic diagrams.Pacing Clin. Electrophys.,8, 691–700.

    Article  Google Scholar 

  • Parsonnet, V., Furman, S. andSmyth, N. P. D. (1981) A revised code for pacemaker identification. ——Ibid.,4, 400–403.

    Article  Google Scholar 

  • Rickards, A. F. andNorman, J. (1981) Relation between AT interval and heart rate. New design of physiologically adaptive cardiac pacemaker.Br. Heart J.,45, 56–61.

    Google Scholar 

  • Selvester, R. H., Solomon, J. andSapoznikov, D. (1979) Computer simulation of the electrocardiogram. InComputer techniques in cardiology.Cady, L. D. (Ed.), Marcel Dekker, New York/Basel, 417–454.

    Google Scholar 

  • Smith, J. M. andCohen, R. J. (1984) Simple finite-element model accounts for wide range of cardiac dysrhythmias.Proc. Nat. Acad. Sci. USA,81, 233–237.

    Article  Google Scholar 

  • Spurrell, R. A. J. andSowton, E. (1976) An implanted atrial synchronous pacemaker with a short atrioventricular delay for the prevention of paroxysmal supraventricular tachycardia.J. Electrocardiol.,9, 89–96.

    Google Scholar 

  • Wartak, J. (1970)Computers in electrocardiography. C.C. Thomas Co., Springfield, Illinois.

    Google Scholar 

  • Zeigler, B. P. (1976)Theory of modelling and simulation. Wiley, New York.

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malik, M., Cochrane, T., Davies, D.W. et al. Clinically relevant computer model of cardiac rhythm and pacemaker/heart interaction. Med. Biol. Eng. Comput. 25, 504–512 (1987). https://doi.org/10.1007/BF02441742

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02441742

Keywords

Navigation