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Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

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Abstract

The role of androgen metabolism and individual androgen metabolites in rat pituitary gland and hypothalamus is discussed on the basis of published data and results of our experiments. It is proposed that metabolism of androgens in these structures is aimed at the formation of not only true sex steroids estradiol-17β and 5α-dihydrotestosterone, but also of androgens contributing to the regulation of cell processes,i.e. represents modification (transformation) of androgen signal (testosterone) in target pituitary and hypothalamic cells.

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  1. N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow

    V. G. Degtyar' & N. E. Kushlinskii

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  1. V. G. Degtyar'
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 484–490, May, 2000

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Degtyar', V.G., Kushlinskii, N.E. Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?. Bull Exp Biol Med 129, 407–412 (2000). https://doi.org/10.1007/BF02439786

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  • DOI: https://doi.org/10.1007/BF02439786

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