Abstract
An attempt was undertaken to evaluate the usefulness of squamous cell carcinoma antigen (SCC Ag) in different stages of squamous cell carcinoma of the larynx. Antigen levels were determined in blood serum before treatment in 25 patients with laryngeal cancer treated at the II ENT Department, Silesian Medical School in Zabrze. Ages were 39–65 years (mean, 56.6 years). Fifteen healthy volunteers of similar ages served as controls. SCC Ag was estimated by an enzyme-immunological method using the Abbot set. Increasing levels of SCC Ag were found in 14 patients (65%). The mean SCC Ag level before treatment in the tumor group was 2.93 ± 0.23 ng/ml and 0.79 ± 0.19 ng/ml in the control group (standard, 1.5 ng/ml). Mean SCC Ag levels depending on the clinical stage of disease were: stage I, 1.52 ng/ml; stage II, 2.16 ng/ml; stage III, 3.03 ng/ml; stage IV, 4.57 ng/ml. Differences in all groups were statistically significant when compared to the healthy controls (P < 0.05).
Similar content being viewed by others
References
Battaglia F, Scambia G, Panici PB, Castelli M, Ferrandina G, Foti E, Amoroso M, D'Andrea G, Manusco S (1994) Immunosuppresive acid protein (IAP) and squamous cell carcinoma antigen (SCC) in patients with cervical cancer. Gynecol Oncol 53:176–182
De Cos JS, Masa F, Cruz JL de la, Disidier C, Vergara C (1994) Squamous cell carcinoma antigen (SCC Ag) in the diagnosis and prognosis of lung cancer. Chest 105: 773–776
Fukanaga M, Otsuka N, Sone T, et al (1985) Clinical study on the measurement of squamous cell carcinoma (SCC)-related antigen in SCC. Gan No Rinsko 31: 1855–1888
Gaast A, Schoenmakers CHH, Kok TC, Blijenberg BG, Comillie F, Splinter TAW (1994) Evaluation of a new tumor marker in patients with non-small-cell lung cancer. Cyfra 21.1. Br J Cancer 69: 525–528
Kato H, Torigoe T (1977) Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. Cancer 40: 1621–1628
Kato H, Morioka H, Aramaki S, Tamai K, Torigoe T (1983) Prognostic significance of the tumor antigen TA-4 in squamous cell carcinoma of the uterine cervix. Am J Obstet Gynecol 145: 350–354
Kato H, Tamai K, Morioka H, Nagai M, Nagaya T, Torigoe T (1984) Tumor-antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma. Cancer 54: 1544–1546
Kobayashi T, Kawakubo T (1994) Prospective investigation of tumor markers and risk assessment in early cancer screening. Cancer 73:1946–1953
Koch WM, Boyle JO, Mao L, Hakim J, Hruban J, Sidransky D (1994) p53 Gene mutatism as markers of tumor spread in synchronous oral cancers. Arch Otolaryngol Head Neck Surg 120: 943–947
Krynska B, Sawicka B, Zawisza E, Andrzejewski A (1991) Ferritin as a neoplasm marker in patients with laryngeal cancer and in precancerous lesions (in Polish). Otolaryngol Pol 45: 241–245
Lachowicz M, Hassmann-Poznanska n (1994) SCC antigen in laryngeal cancer patients (in Polish). Otolaryngol Pol 48 [Suppl 16]: 41–43
Mevio E, Benazzo M, Galioto P, Spriano P, Pizzala R (1991) Use of serum markers in the diagnosis and management of laryngeal cancer. Clin Otolaryngol 16: 90–92
Munck-Wikland E, Fernberg JO, Kuylenstierna R, Lindholm J, Auer G (1993) Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer. Eur J Cancer B Oral Oncol 29: 75–79
Schatz C, Mulders M, Rowold J, Stracke H, Muler H, Grebe SF, Shatz H (1985) Die Tumormarker CEA, TPA and CA 19-9 Bowie Ferritin and Osteocalcin in der Verlaufskontolle bei Mammakarzinom. Wien Klin Wochanschr 97: 873–879
Straka MB, Wagner RL, Johnson JT, Kachman KK, Eibling DE (1992) The lack of utility of a tumor marker panel in head and neck carcinoma. Arch Otolaryngol Head Neck Surg 118: 802–805
Szymendera J (1982) Role of biochemical neoplasm markers in diagnosis and monitoring of neoplasm process (in Polish). Nowotwory 32: 7–17
Tamas L, Sziklai I, Ribari O, Repassy G (1993) A peptide-like putative marker substance of laryngeal cancer patients. Eur Arch Otorhinolaryngol 250: 157–160
Tomaszewski L (1986) Biochemical markers in neoplastic disease (in Polish). Pol Tyg Lek 41: 091–1098
Yamanaka N, Himi T, Harabuchi Y, Hoki K, Kataura A (1988) Soluble immune complexes and squamous cell carcinoma related antigens in patients with head and neck cancer. Cancer 62:1932–1988
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Namyslowski, G., Klimala, J., Kokocinska, D. et al. Squamous cell carcinoma antigen levels in patients with different stages of laryngeal cancer. Eur Arch Otorhinolaryngol 254 (Suppl 1), S154–S156 (1997). https://doi.org/10.1007/BF02439749
Issue Date:
DOI: https://doi.org/10.1007/BF02439749