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AlleleNAT2 *5determines resistance to bronchial asthma in children

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

NAT2*5 allele was found in 54.8% healthy children and 35.9% children with bronchial asthma,i.e. the risk of bronchial asthma was considerably lower in individuals carryingNAT2*5 allele.NAT2*5 allele manifests itself in both homo- and heterozygous states.

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References

  1. Bronchial Asthma. Global Strategy [in Russian],Pulmonologiya, Supplement (1996).

  2. V. V. Ivanova L. N. Bulovskaya, G. F. Zheleznikova, and O. A. Drobachenko,Immunologiya,6, 45–47 (1997).

    Google Scholar 

  3. D. Hickman, J. R. Palamanda, J. D. Unadkay, and E. Sim,Biochem. Pharmacol.,50, No. 5, 697–703 (1995).

    Article  PubMed  CAS  Google Scholar 

  4. A. L. Hubbard, D. J. Harrison, A. H. Wyllie,et al., Gut.,41, 229–234 (1997).

    Article  PubMed  CAS  Google Scholar 

  5. P. D. Josephy, D. H. Evans, A. Parikh, and F. P. Guengerich,Chem. Res. Toxicol.,11, 70–74 (1998).

    Article  PubMed  CAS  Google Scholar 

  6. J. Jouve, J. Herault, H. Tournade, and J. P. Muh,J. Chromatogr.,574, 9–15 (1992).

    PubMed  CAS  Google Scholar 

  7. J. T. Li,Curr. Opin. Pulm. Med.,3, 10–16 (1997).

    PubMed  CAS  Google Scholar 

  8. K. Orzechovska-Juzwenko, P. Milejski, J. Patkowski,et al., Int. J. Clin. Pharmacol. Ther. Toxicol.,28, No. 10, 420–425 (1990).

    Google Scholar 

  9. N. Pearse,Int. J. Epidemiol.,22, 1189–1192 (1993).

    Google Scholar 

  10. A. Sandford, T. Weir, and P. Pare,Am. J. Respir. Crit. Care Med.,153, 1749–1765 (1996).

    PubMed  CAS  Google Scholar 

  11. J. A. Smith, P. S. Helliwell, A. Isdaleet al., J. Pineal. Res.,10, No. 1, 14–17 (1991).

    PubMed  CAS  Google Scholar 

  12. K. P. Vatsis, W. W. Weber, D. A. Bell,et al., Pharmacogenetics,5, 1–18 (1995).

    PubMed  CAS  Google Scholar 

  13. W. Wang and N. Ballatori,Pharmacol. Rev.,50, No. 3, 335–354 (1998).

    PubMed  CAS  Google Scholar 

  14. W. W. Weber and L. W. Hein,—Ibid.,,37 25–79 (1985).

    PubMed  CAS  Google Scholar 

  15. N. M. Woolhouse, M. M. Quereshi, S. M. A. Bastaki,et al., Pharmacogenetics 7, 73–82 (1997).

    PubMed  CAS  Google Scholar 

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Correspondence to S. I. Makarova.

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Makarova, S.I., Vavilin, V.A., Lyakhovich, V.V. et al. AlleleNAT2 *5determines resistance to bronchial asthma in children . Bull Exp Biol Med 129, 575–577 (2000). https://doi.org/10.1007/BF02434881

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  • DOI: https://doi.org/10.1007/BF02434881

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