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Effect of tetrahydrocortisol on protein biosynthesis in hepatocytes

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cooperative effect of high-density lipoproteins and glucocorticoids on protein biosynthesis in hepatocytes was associated with the formation of biologically active hormone in Kupffer cells. Apolipoprotein A-I, a constituent of high-density lipoproteins, transported the active hormone from liver macrophages to hepatocytes. Apolipoprotein A-I-induced stimulation of protein biosynthesis was observed only in Kupffer cells. Apolipoprotein A-I alone or in combination with hormones did not change the rate of protein biosynthesis in liver endotheliocytes.

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Authors and Affiliations

  1. Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    L. E. Panin, I. F. Usynin & A. V. Khar'kovskii

Authors
  1. L. E. Panin
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  2. I. F. Usynin
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  3. A. V. Khar'kovskii
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 171–173, February, 2000

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Panin, L.E., Usynin, I.F. & Khar'kovskii, A.V. Effect of tetrahydrocortisol on protein biosynthesis in hepatocytes. Bull Exp Biol Med 129, 146–148 (2000). https://doi.org/10.1007/BF02434794

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  • DOI: https://doi.org/10.1007/BF02434794

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