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Antioxidant probucol as an effective scavenger of lipid radicals in low density lipoproteinsin vivo andin vitro

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Probucol in concentrations of 10–15 μM effectively inhibits Cu2+-induced free radical oxidation of native low density lipoproteins and in concentration of 100 μM it inhibits lipoperoxide formation. The mean plasma concentration of probucol in patients receiving 250 mg of this drug is 25 μM. Both 250 and 1000 mg probucol daily during 3–6 month block the oxidation of isolated low density lipoproteins. Electron paramagnetic resonance spectrometry data showed that probucol incorporatedin vivo into lipoprotein particles interacts with lipid radicals yielding long-lived phenoxyradicals. Probucol can be used in complex therapy of atherosclerosis as an antioxidant drug and its dose required for lipoprotein protection against atherogenic modification can be decreased to 250 mg/day.

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Authors and Affiliations

  1. Laboratory of Biochemistry of Free Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow

    A. K. Tikhaze, B. Z. Lankin, G. G. Konovalova, K. B. Shumaev, A. I. Kaminnyi, A. I. Kozachenko, S. M. Gurevich, L. G. Nagler, T. M. Zaitseva & V. V. Kukharchuk

Authors
  1. A. K. Tikhaze
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  2. B. Z. Lankin
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  3. G. G. Konovalova
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  4. K. B. Shumaev
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  5. A. I. Kaminnyi
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  6. A. I. Kozachenko
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  7. S. M. Gurevich
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  8. L. G. Nagler
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  9. T. M. Zaitseva
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  10. V. V. Kukharchuk
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 186–189, August, 1999

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Tikhaze, A.K., Lankin, B.Z., Konovalova, G.G. et al. Antioxidant probucol as an effective scavenger of lipid radicals in low density lipoproteinsin vivo andin vitro . Bull Exp Biol Med 128, 818–821 (1999). https://doi.org/10.1007/BF02433824

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  • DOI: https://doi.org/10.1007/BF02433824

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