Summary
This anatomical study was designed to evaluate the concept that reduced blood flow through the embryonic preductal aorta contributes to the pathogenesis of dimensional aortic arch anomalies. For that purpose the intracardiac anatomy of 151 specimens was examined, of which 22 had an interruption, five atresia, 76 tubular hypoplasia, and 48 local coarctation of the aortic arch. Associated malformations were found in 148 specimens (98%); the remaining three (2%) had isolated local coarctation. Anomalies predisposing to reduced aortic blood flow were present in 128 specimens (85%). Among the potential obstructive factors affecting early morphogenesis, three left ventricular muscular structures seem to be particularly important: (1) the anterolateral muscle bundle, (2) the posteromedial muscle, and (3) leftward deviation of the anterior part of the ventricular septum. Obstructing combinations with these types of anomaly were identified in 77 cases (51%). The embryologic aspects of these muscular structures are discussed.
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Bruins C: Competition between aortic isthmus and ductus arteriosus: Reciprocal influence of structure and flow.Eur J Cardiol 8:87–97, 1978
Congdon ED: Transformation of the aortic arch system during the development of the human embryo.Contrib Embryol 14:47–110, 1922
Devloo-Blancquaert A, Ritter DG: Muscle ridge between atrioventricular valves and malalignment of junction of these valves with ventricular septum.Br Heart J 40:1267–1274, 1978
Freedom RM, Dische MR, Rowe RD: Pathologic anatomy of subaortic stenosis and atresia in the first year of life.Am J Cardiol 39:1035–1044, 1977
Lev M, Liberthson RR, Kirkpatrick JR, Eckner FAO, Arcilla RA: Single (primitive) ventricle.Circulation 39:579–591, 1969
Moore GW, Hutchins GM: Association of interrupted aortic arch with malformations producing reduced blood flow to the fourth aortic arches.Am J Cardiol 42:467–472, 1978
Moulaert AJ:Ventricular Septal Defects and Anomalies of the Aortic Arch, thesis. University of Leiden, 1974
Moulaert AJ, Oppenheimer-Dekker A: Anterolateral muscle bundle of the left ventricle, bulboventricular flange and subaortic stenosis.Am J Cardiol 37:78–81, 1976
Moulaert AJ, Bruins CC, Oppenheimer-Dekker A: Anomalies of the aortic arch and ventricular septal defects.Circulation 53:1011–1015, 1976
Oppenheimer-Dekker A: Development of the chorionic vascular network with reference to the transformation of the aortic branchial arteries in 10–20 mm human embryos (sixth week).J Anat 120:399–400, 1975
Oppenheimer-Dekker A: Interventricular communications in transposition of the great arteries, in Van Mierop LHS, Oppenheimer-Dekker A, Bruins CLDC (eds):Embryology and Teratology of the Heart and Great Arteries. The Hague, Martinus Nijhoff, 1978, p 150
Oppenheimer-Dekker A, Moene RJ, Moulaert AJ, Gittenberger-de Groot AC: Teratogenetic considerations regarding aortic arch anomalies associated with cardiovascular malformations, inPerspectives in the Cardiovascular Research, 5:485–500, 1981
Rudolph AM:Congenital Diseases of the Heart. Chicago, Year Book Medical Publishers Inc, 1974
Rudolph AM, Heyman MA, Spitznas U: Hemodynamic considerations in the development of narrowing of the aorta.Am J Cardiol 30:514–525, 1972
Rychter Z: Experimental morphology of the aortic arches and the heart loop in chick embryos.Adv Morphogenesis 2:333–371, 1962
Shinebourne EA, Elseed AM: Relation between fetal flow patterns, coarctation of the aorta, and pulmonary blood flow.Br Heart J 36:492–498, 1974
Van Praagh R, Bernhard WF, Rosenthal A, Parisi LF, Fyler DC: Interrupted aortic arch: surgical treatment.Am J Cardiol 27:200–211, 1971
Wenink ACG: Embryology of the conducting system, in Van Mierop LHS, Oppenheimer-Dekker A, Bruins CLDC (eds):Embryology and Teratology of the Heart and Great Arteries. The Hague, Martinus Nijhoff, 1978, p 3
Wenink ACG: Considerations pertinent to the embryogenesis of transposition. In Van Mierop LHS, Oppenheimer-Dekker A, Bruins CLDC (eds):Embryology and Teratology of the Heart and Great Arteries. The Hague, Martinus Nijhoff, 1978, p 129
Wenink ACG, Oppenheimer-Dekker A, Moulaert AJ: Muscular ventricular septal defects: A reappraisal of the anatomy.Am J Cardiol 43:259–264, 1979
Wenink ACG: The conducting tissues in normal and congenitally malformed hearts, in Squarcia U (ed):Progressi in Cardiologia Pediatrica, to be published
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Supported by the Netherlands Heart Foundation, The Hague, the Netherlands
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Moene, R.J., Oppenheimer-Dekker, A., Moulaert, A.J. et al. The concurrence of dimensional aortic arch anomalies and abnormal left ventricular muscle bundles. Pediatr Cardiol 2, 107–114 (1982). https://doi.org/10.1007/BF02424945
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DOI: https://doi.org/10.1007/BF02424945