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Restriction fragment analysis of non-deleted complementC4 null genes suggests point mutations inC4A null alleles, but gene conversions inC4B null alleles

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References

  • Belt, T.K., Carroll, M.C., and Porter, R.R.: The structural basis of the multiple forms of human complement component C4.Cell 36: 907–914, 1984

    Article  CAS  PubMed  Google Scholar 

  • Campbell, R.D., Law, S.K.A., Reid, K.B.M., and Sim, R.B.: Structure, organisation, and regulation of the complement genes.Annu Rev Immunol 6: 161–195, 1988

    Article  CAS  PubMed  Google Scholar 

  • Palsdottir, A., Arnason, A., Fossdal, R., and Jensson, O.: Gene organisation of haplotypes expressing two different C4A allotypes.Hum Genet 76: 220–224, 1987

    Article  CAS  PubMed  Google Scholar 

  • Partanen, J., Koskimies, S., and Johansson, E.: C4 null phenotypes among lupus erythematosus patients are predominantly the result of deletions covering C4 and closely linked 21-hydroxylase A genes.J Med Genet 25: 387–391, 1988

    Article  CAS  PubMed  Google Scholar 

  • Partanen, J., Koskimies, S., Sipila, I., and Lipsanen, V.: Majorhistocompatibility-complex gene markers and restriction-fragment analysis of steroid 21-hydroxylase (CYP21) and complement C4 genes in classical congenital adrenal hyperplasia patients in a single population.Am J Hum Genet 44: 660–670, 1989a

    CAS  PubMed  Google Scholar 

  • Partanen, J., Kere, J., Wessberg, S., and Koskimies, S.: Determination of deletion sizes in the MHC-linked complement C4 and steroid 21-hydroxylase genes by pulsed-field gel electrophoresis.Genomics 5: 345–349, 1989b

    Article  CAS  PubMed  Google Scholar 

  • Schneider, P.J., Carroll, M.C., Alper, C.A., Rittner, C., Whitehead, A.S., Yunis, E.J., and Colten, H.R.: Polymorphism of the human complement C4 and steroid 21-hydroxylase genes.J Clin Invest 78: 650–657, 1986

    Article  CAS  PubMed  Google Scholar 

  • White, P.C., New, M.I., and Dupont, B.: Structure of human steroid 21-hydroxylase genes.Proc Natl Acad Sci USA 83: 5111–5115, 1986

    CAS  PubMed  Google Scholar 

  • Yu, C.Y. and Campbell, R.D.: Definitive RFLPs to distinguish between the human complement C4A/C4B isotypes and the major Rodgers/Chido determinants: application to the study ofC4 null alleles.Immunogenetics 25: 383–390, 1987

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Kivihaantie 7, SF-00310, Helsinki, Finland

    Jukka Partanen Ph.D.

  2. MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK

    R. Duncan Campbell

Authors
  1. Jukka Partanen Ph.D.
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  2. R. Duncan Campbell
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Partanen, J., Campbell, R.D. Restriction fragment analysis of non-deleted complementC4 null genes suggests point mutations inC4A null alleles, but gene conversions inC4B null alleles. Immunogenetics 30, 520–523 (1989). https://doi.org/10.1007/BF02421186

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  • DOI: https://doi.org/10.1007/BF02421186

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