Summary
To clarify perinatal vitamin D metabolism, we measured 25-hydroxyvitamin D (25OHD), 24,25-dihydroxyvitamin D [24,25(OH)2D], 1,25-dihydroxyvitamin D [1,25(OH)2D], calcium (Ca), phosphorus (P), parathyroid hormone (PTH), and human calcitonin (CT) in paired maternal, cord, and infant serum. Cord serum 25OHD was significantly lower than the maternal level, and cord serum 24,25(OH)2D was also significantly below the maternal concentrations. Maternal, cord, and infant serum 1,25(OH)2D, on the other hand, was significantly higher than the normal adult level. The serum PTH was low, but the CT concentration was high in the cord. Cord serum Ca and P levels were significantly higher than maternal. The reason for the elevated circulating 1,25(OH)2D level in the perinatal period is uncertain, and we speculate that the possible factors are gonadal steroids, placental lactogen, prolactin, and CT. In addition, serum 24,25(OH)2D and 1,25(OH)2D concentrations are under some control by the fetus.
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References
Edelstein S, Ornoy A (1979) 24,25-Dihydroxyvitamin D: the preferred metabolite for bone. In: Norman AW, Schaefer K, Herrath DV, Grigoleit H-G, Coburn JW, DeLuca HF, Mawer EB, Suda T (eds) Vitamin D Basic Research and Its Clinical Application. Walter de Gruyter, New York Berlin, pp 381–389
Tanaka Y, DeLuca HF, Ikekawa N (1979) A study of the physiologic significance of 24-hydroxylation of 25-hydroxyvitamin D. In: Norman AW, Schaefer K, Herrath DV, Grigoleit H-G, Coburn JW, DeLuca HF, Mawer EB, Suda T (eds) Vitamin D Basic Research and Its Clinical Application. Walter de Gruyter, New York Berlin, pp 531–536
Steichen JJ, Tsang RC, Gratton TL, Hamstra A, DeLuca HF: (1980) Vitamin D homeostasis in the perinatal period. N Engl J Med 302:315–319
Shimotsuji T, Seino Y (1980) Competitive protein binding assay for 25-hydroxycholecalciferol. Methods Enzymol 67:466–472
Shimotsuji T, Hiejima T, Seino Y, Yamaoka K, Ishii T, Ishida M, Matsuda S, Ikahara C, Yabuuchi H (1980) A specific competitive protein binding assay for serum 24,25-dihydroxyvitamin D in normal children and in the nephrotic syndrome. Clin Chim Acta 106:145–154
Seino Y, Shimotsuji T, Yamaoka K, Ishida M, Ishii T, Matsuda S, Ikehara C, Yabuuchi H, Dokoh S (1980) Plasma 1,25-dihydroxyvitamin D concentrations in cords, new-borns, infants and children. Calcif Tissue Int 30:1–3
Morimoto S, Onishi T, Okada Y, Tanaka K, Tsuji M, Kumahara Y (1978) Comparison of human calcitonin secretion after a 1-minute calcium infusion in young normal and in elderly subjects. Endocrinol Jpn 25:617–622
Bouillon R, Baelen HV, Moor PD (1977) The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab 45:225–231
DeLuca HF (1980) The vitamin D system in the regulation of calcium and phosphorus metabolism. Nutr Rev 37:161–193
Hillman LS, Slatopolsky E, Haddad JG (1978) Perinatal vitamin D metabolism. IV. Maternal and cord serum 24,25-dihydroxyvitamin D concentrations. J Clin Endocrinol Metab 47:1073–1077
Spanos E, Barrett D, MacIntyre I, Pike JW, Safilian EF, Haussler MR (1980) Effect of growth hormone on vitamin D metabolism. Nature 273:246–247
Weisman Y, Harell A, Edelstein S, David M, Spirer Z, Golander A (1979) 1α,25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Nature 281:317–319
Bouillon R, Baellen HV, Moor PD (1977) 25-Hydroxyvitamin D and its binding protein in maternal and cord serum. J Clin Endocrinol Metab 45:679–684
Winters AJ, Colston C, MacDonald PC, Porter JC (1975) Fetal plasma prolactin levels. J Clin Endocrinol Metab 41:626–629
Hillman LS, Rojanasathit S, Slatopolsky E, Haddad JG (1977) Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxyvitamin D in premature and term infants during the first week of life. Pediatr Res 11:739–744
Horiuchi N, Takahashi H, Matsumoto T, Takahashi N, Shimazawa E, Suda T, Ogata E (1979) Salmon calcitonin-induced stimulation of 1α,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3′:5′-cyclic monophosphate. Biochem J 184:269–275
Kumar R, Cohen WR, Epstein FH (1980) Vitamin D and calcium hormones in pregnancy. N Engl J Med 302:1143–1145
Shepard RM, Horst RL, Hamstra AJ, DeLuca HF (1979) Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J 182:55–69
Lambert PW, Syverson BJ, Arnaud CD, Spelsberg TC (1977) Isolation and quantitation of endogenous vitamin D and its physiologically important metabolites in human plasma by high pressure liquid chromatography. J Steroid Biochem 8:929–937
Horst RL, Shepard RM, Jorgensen NA, DeLuca HF (1979) The determination of 24,25-dihydroxyvitamin D and 25,26-dihydroxyvitamin D in plasma from normal and nephrectomized man. J Lab Clin Med 93:277–285
Shimotsuji T, Seino Y, Ishida M, Ishii T, Ikehara C, Hiejima T, Yabuuchi H (1979) Relations of plasma 25-hydroxyvitamin D levels in mothers, cord blood and newborn infants and postnatal changes in plasma 25-hydroxyvitamin D levels. J Nutr Sci Vitam 25:79–86
Weisman Y, Occhipinti M, Knox G, Reiter E, Root A (1978) Concentrations of 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D in paired maternal-cord sera. Am J Obstet Gynecol 130:704–707
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Seino, Y., Ishida, M., Yamaoka, K. et al. Serum calcium regulating hormones in the perinatal period. Calcif Tissue Int 34, 131–135 (1982). https://doi.org/10.1007/BF02411223
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DOI: https://doi.org/10.1007/BF02411223