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Variations in mineral apposition rate of trabecular bone within the beagle skeleton

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Summary

The mineral apposition rate of trabecular bone was determined in several skeletal sites of young adult beagles. Tetracycline derivatives were administered intravenously or orally on 2 separate occasions preceding the day of sacrifice in order to label actively mineralizing bone surfaces. The rate of mineral apposition was calculated by dividing the distance between the 2 tetracycline markers by the time interval between their administration. The lumbar vertebra, proximal humerus, and pelvis, each of which contains red marrow, were found to have a significantly higher (P<0.001) rate of mineral apposition in trabecular bone than the skeletal sites containing yellow marrow—the proximal ulna and distal humerus. The mean apposition rate in the former 3 sites was 1.3±0.3µm/day, while that in the latter 2 was 0.9±0.2µm/day (uncorrected for plane of sectioning). It is tempting to speculate that this finding may be a consequence of differences in vascularity between red and yellow marrow.

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Authors and Affiliations

  1. Department of Pharmacology, Radiobiology Division, University of Utah College of Medicine, 84112, Salt Lake City, Utah, USA

    T. J. Wronski, J. M. Smith & W. S. S. Jee

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  1. T. J. Wronski
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  2. J. M. Smith
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  3. W. S. S. Jee
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Wronski, T.J., Smith, J.M. & Jee, W.S.S. Variations in mineral apposition rate of trabecular bone within the beagle skeleton. Calcif Tissue Int 33, 583–586 (1981). https://doi.org/10.1007/BF02409495

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  • DOI: https://doi.org/10.1007/BF02409495

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