Abstract
The de novo creation of long, homogeneous, satellite DNA domains was postulated previously to occur by saltatory amplification. In this paper, pulsed field gel electrophoresis analysis of the α satellite DNA block organization of the human chromosome 21 supports this hypothesis.
Double-dimension electrophoresis indicated that the variant copies of the basic α satellite repeat of chromosome 21 are organized in a single 3,150 Kblong domain. It was also established that the other satellite DNAs found in man (β, II, and III) are organized independently of the α satellite DNA block of the same chromosome.
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Marçais, B., Laurent, AM., Charlieu, JP. et al. Organization of the variant domains of α satellite DNA on human chromosome 21. J Mol Evol 37, 171–178 (1993). https://doi.org/10.1007/BF02407353
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DOI: https://doi.org/10.1007/BF02407353