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Interrelation of cortisone and 1,25 dihydroxycholecalciferol on intestinal calcium and phosphate absorption

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Summary

The interrelation of glucocorticoids and 1,25 dihydroxycholecalciferol (1,25(OH)2D3) on intestinal calcium and phosphate absorption was investigated. The active and passive transport of calcium and phosphate was evaluated by thein situ intestinal loop technique. Administration of cortisone resulted in a decrease of the luminal fluid and an increase of the luminal calcium and phosphate concentration. Under active transport conditions, administration of cortisone resulted in a decrease of net calcium absorption through two mechanisms: (1) depressed vitamin D-dependent calcium absorption, (2) increased vitamin D-independent calcium backflux. The enhancement of bidirectional phosphate flux by cortisone was independent of 1,25(OH)2D3. An enhancement of water movement by cortisone resulted in an increase of luminal calcium and phosphate concentration which favors the passive diffusion of these ions. Enhanced calcium diffusion by cortisone compensates for the inhibitory effect of cortisone on vitamin D-dependent calcium transport. However, enhanced phosphate diffusion by cortisone is additive to the effect of 1,25(OH)2D3.

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References

  1. Kimberg DV, Baerg RD, Gershon E, Graudusius RT (1971) Effect of cortisone treatment on the active transport of calcium by the small intestine. J Clin Invest 50:1309–1321

    CAS  PubMed  Google Scholar 

  2. Favus MJ, Walling MW, Kimberg DV (1973) Effects of 1,25-dihydroxycholecalciferol on intestinal calcium transport in cortisone-treated rats. J Clin Invest 52:1680–1685

    Article  CAS  PubMed  Google Scholar 

  3. Hahn TJ (1980) Drug-induced disorders of vitamin D and mineral metabolism. Clin Endocrinol Metab 9:107–127.

    Article  CAS  PubMed  Google Scholar 

  4. Seeman E, Kumar R, Hunder GG, Scott M, Heath H III, Riggs BL (1980) Production, degradation and circulating levels of 1,25-dihydroxy-vitamin D in health and in chronic glucocorticoid excess. J Clin Invest 66:664–669

    CAS  PubMed  Google Scholar 

  5. Hahn TJ, Halstead LR, Baran DT (1981) Effects of short-term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 52:111–115

    CAS  PubMed  Google Scholar 

  6. Favus MJ, Kimberg DV, Millar GN, Gershon E (1973) Effects of cortisone administration on the metabolism and localization of 25-hydroxycholecalciferol in the rat. J Clin Invest 52:1328–1335

    CAS  PubMed  Google Scholar 

  7. Hirst M, Feldman D (1982) Glucocorticoid regulation on 1,25(OH)2-vitamin D receptors: divergent effects on mouse and rat intestine. Endocrinol 111:1400–1402

    CAS  Google Scholar 

  8. Feher JJ, Wasserman RH (1979) Intestinal calcium-binding protein and calcium absorption in cortisone-treated chicks: effects of vitamin D and 1,25-dihydroxyvitamin D3. Endocrinol 104:547–551

    Article  CAS  Google Scholar 

  9. Corradino RA (1979) Embryonic chick intestine in organ culture: hydrocortisone and vitamin D-mediated processes. Arch Biochem Biophys 192:302–310

    Article  CAS  PubMed  Google Scholar 

  10. Krawitt El (1972) The role of intestinal transport proteins in cortisone-mediated suppression of calcium absorption. Biochim Biophys Acta 274:179–188

    CAS  PubMed  Google Scholar 

  11. Frizzel RA, Schultz SG (1972) Ionic conductances of extracellular shunt pathway in rabbit ileum. J General Physiol 59:318–346

    Article  Google Scholar 

  12. Yeh JK, Aloia JF (1981) Effect of cortisone on intestinal phosphate absorption in the rat. Mineral Electrolyte Metab 6:274

    Google Scholar 

  13. Yeh JK, Aloia JF (1982) Reevaluation of the effect of glucocorticoids on intestinal calcium absorptin in the rat. Fourth Annual Scientific Meeting of the American Society for Bone and Mineral Research P. S24

  14. Walling MW (1977) Intestinal Ca and phosphate transport: differential responses to vitamin D3 metabolites. Am J Physiol 233:E488-E494

    CAS  PubMed  Google Scholar 

  15. Morrissey RL, Wasserman RH (1971) Calcium absorption and calcium binding protein in chicks on differing calcium and phosphorous intakes. Am J Physiol 220:1509–1515

    CAS  PubMed  Google Scholar 

  16. Schedl H, Clifton J (1966) Small intestine absorption of steroids. Gastroenterology 41:491–499

    Google Scholar 

  17. Fiske CH, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66:375–400

    CAS  Google Scholar 

  18. Krawitt EL, Kunin AS, Sampson HW, Bacon BF (1977) Effect of hypophysectomy on calcium transport by rat duodenum. Am J Physiol 232:E229-E233

    CAS  PubMed  Google Scholar 

  19. Adams JS, Lukert BP (1980) Effects of sodium restriction on45Ca and22Na transduodenal flux in corticosteroidtreated rats. Mineral Electrolyte Metab 4:216–226

    CAS  Google Scholar 

  20. Norman DA, Morawski SG, Fordtran JS (1980) Influence of glucose, fructose and water movement on calcium absorption in the jejunum. Gastroenterology 78:22–25

    CAS  PubMed  Google Scholar 

  21. Ferraro C, Ladizesky M, Cabrejas M, Montoreano R, Mautalen C (1976) Intestinal absorption of phosphate: action of protein synthesis inhibitors and glucocorticoids in the rat. J Nutr 106:1752–1756

    CAS  PubMed  Google Scholar 

  22. Corradino RA (1979) Hydrocortisone and vitamin D3 stimulation of32Pi-phosphate accumulation by organ-cultured chick embryo duodenum. Horm Metab Res 11:519–523

    Article  CAS  PubMed  Google Scholar 

  23. Aloia JF, Semla HM, Yeh JK (1984) Discordant effects of glucocorticoids on active and passive transport of calcium in the rat duodenum. Calcif Tissue Int 36:327–331

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Nassau Hospital, Mineola, N.Y., USA

    James K. Yeh, John F. Aloia M.D. & Halina M. Semla

  2. Health Sciences Center, State University of New York at Stony Brook, USA

    James K. Yeh, John F. Aloia M.D. & Halina M. Semla

Authors
  1. James K. Yeh
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  2. John F. Aloia M.D.
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  3. Halina M. Semla
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Yeh, J.K., Aloia, J.F. & Semla, H.M. Interrelation of cortisone and 1,25 dihydroxycholecalciferol on intestinal calcium and phosphate absorption. Calcif Tissue Int 36, 608–614 (1984). https://doi.org/10.1007/BF02405375

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  • DOI: https://doi.org/10.1007/BF02405375

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