Abstract
Levels of CA-125 were determined pre- and postoperatively in 13 patients with Fallopian tube cancer. Values before surgery were significantly higher (Median 1220 IU/ml, 90–5000 IU/ml) compared with postoperative levels (Median 194 IU/ml, 67–880 IU/ml) (P=0.0052). Correlation analysis with FIGO stage and grading failed to show any statistical significance, but a trend for a positive correlation with FIGO stage and preoperative values could be observed. The CA-125 antigen is expressed by Fallopian tube carcinoma and should therefore be used in diagnosis and follow-up.
Similar content being viewed by others
References
Bast RC, Klug TL, St. John E (1983) A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 309:883–887
Berek JS, Knapp RC, Malkasian GD (1986) CA-125 serum levels correlated with second-look operations among ovarian cancer patients. Obstet Gynecol 67:685–689
Crombach G, Zippel HH, Würz H (1985) Erfahrungen mit CA-125, einem Tumormarker für maligne epitheliale Ovarialtumoren. Geburtshilfe Frauenheilkd 45:205–212
Davis AP, Fish A, Woolas R, Oram D (1991) Raised serum CA-125 preceding the diagnosis of carcinoma of the fallopian tube: two case reports. Br J Obstet Gynecol 98:602–603
Dodson MG, Ford JH, Averette HE (1970) Clinical aspects of Fallopian tube carcinoma. Obstet Gynecol 36:935–939
Einhorn N, Bast RC, Knapp RC, Tjernberg B, Zurawski VR (1986) Preoperative evaluation od serum CA-125 levels in patients with primary epithelial ovarian cancer. Obstet Gynecol 67:414–416
Engeler V, Reinisch E, Schreiner WE (1981) Das primäre Tubenkarzinom. Eine klinische Studie an 37 Patientinnen. Geburtshilfe Frauenheilkd 41:325–329
Hanton EM, Malkasian GD, Dahlin DC, Pratt J (1966) Primary carcinoma of the Fallopian tube. Am J Obstet Gynecol (1966) 94:832–839
Hu CY, Taymor ML, Hertig AT (1950) Primary carcinoma of the fallopian tube. Am J Obstet Gynecol 59:58–67
Jones OV (1965) Primary carcinoma of the uterine tube. Obstet Gynecol 26:122
Klug TL, Bast R, Niloff J, Knapp R, Maroski V (1984) Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA-125) associated with human epithelial ovarian carcinomas. Cancer Res 44:1084–1053
Lootsma-Miklosova E, Aalders JG, Willemse PH, de Bruijn HW (1987) Levels of CA-125 in patients with recurrent carcinoma of the fallopian tube: two case histories. Eur J Obstet Gynecol Reprod Biol 24:231–235
Niloff JM, Knapp RC, Schaetzl E, Reynolds C, Bast RC (1984) CA-125 antigen levels in obstetrics and gynecologic patients. Obstet Gynecol 64:703–707
Niloff JM, Klug TL, Schaetzl E, Zurawski VR, Knapp RC, Bast RC (1984) Elevation of serum CA-125 in carcinoma of the fallopian tube, endometrium and endocervix. Am J Obstet Gynecol 146:1057–1058
Niloff JM, Bast RC, Schaetzl EM, Knapp RC (1985) Predictive value of CA-125 antigen levels in second-look procedures for ovarian cancer. Am J Obstet Gynecol 151:981–986
Rosen A, Sevelda P, Klein M, Spona J, Beck A (1990) A CA-125 score as a prognostic index in patients with ovarian cancer. Arch Gynecol Obstet 247:125–129
Rosen AC, Klein M, Lahousen M, Graf AH, Rainer A, Vavra N (1993) Primary Fallopian carcinoma in Austria. A retrospective multicenterstudy. Br J Cancer 67:605–609
Sevelda P, Salzer H, Dittrich Ch, Pateisky N, Spona J (1987) The diagnostic validity of the tumor marker CA-125 in ovarian cancer patients. Tumor Diagnostik Ther 8:115–120
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rosen, A.C., Klein, M., Rosen, H.R. et al. Preoperative and postoperative CA-125 serum levels in primary Fallopian tube carcinoma. Arch Gynecol Obstet 255, 65–68 (1994). https://doi.org/10.1007/BF02391799
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02391799