Abstract
Objective: To evaluate the impact of postoperative therapy (chemotherapy vs. irradiation) on overall survival.Design: A nationwide retrospective analysis.Setting: Hanusch-Krankenhaus, Department of Gynaecology.Subjects: 115 patients with histologically proved primary carcinoma of the Fallopian tube: 49 received six treatment cycles of a cis-platinum regimen (group I), 24 patients were treated by full irradiation using 50 Gray minimum (group II). The two groups had a similar distribution of stage I and II; in the more advanced stages chemotherapy was the predominant method of treatment.Results: The five-year survival rate was 53% for women receiving irradiation as against 27% for those given cis-platinum. If the analysis was restricted to those patients with comparable stage I and stage II lesions, the p-value (0.07) was of borderline significance. There was no advantage in adding abdominal to pelvic irradiation (P=0.62).Conclusions: Stage I and stage II carcinoma is probably better treated postoperatively by radiotherapy than chemotherapy. Chemotherapy may have more therapeutic potential in patients with more advanced lesions.
Similar content being viewed by others
References
Benedet JL, White GW, Fairey RN, Boyes DA (1977) Adenocarcinoma of the fallopian tube-experience with 42 patients. Obstet Gynecol 50:654–657
Denham JW, Maclennan KA (1984) The management of primary carcinoma of the Fallopian tube-experience of 40 cases. Cancer 53:166–172
Dodson JW, Ford JH, Averette HE (1970) Clinical aspects of Fallopian tube carcinoma. Obstet Gynecol 36:935–939
Eddy GL, Copeland LJ, Gershenson DM, Atkinson EN, Wharton JT, Rutledge FN (1984) Fallopian tube carcinoma. Obstet Gynecol 64:546–552
Engeler V, Reinisch E, Schreiner WE (1981) Das primäre Tubenkarzinom — eine klinische Studie an 37 Patientinnen. Geburshilfe Frauenheilkd 41:325–329
Hershey D, Fennell R, Major F (1981) Primary carcinoma of the Fallopian tube. Obstet Gynecol 57:58–67
Hu CY, Taymor ML, Hertig AT (1950) Primary carcinoma of the Fallopian tube. Am J Obstet Gynecol 59:58–67
Klein M, Rosen A, Lahousen M, Graf A, Vavra N, Beck A (1993) Radical lymphadenectomy in the primary carcinoma of the Fallopian tube. Arch Obstet Gynecol (in press)
McMurray EH, Jacobs AJ, Perez CA, Camel HM, Kao M, Galakatos A (1986) Carcinoma of the Fallopian tube — management and sites of failure. Cancer 58:2070–2075
Morris M, Gershenson DM, Burke TW, Kavanagh JJ, Silva EG, Wharton JT (1990) Treatment of Fallopian tube carcinoma with cisplatin, doxorubicin, and cyclophosphamid. Obstet Gynecol 76:1020–1023
Pakisch B, Poschauko J, Stücklschweiger G, Poier E, Lahousen M, Pickel H, Kohek P, Klug P, Hackl A (1990) Die Behandlung des primären Karzinoms der Ruba Fallopii. Geburtshilfe Frauenheilkd 50:593–596
Pfeiffer P, Mogensen H, Amtrup F, Honore E (1989) Primary carcinoma of the Fallopian tube. Acta Oncolog 28:7–11
Tamini HK, Figge DC (1981) Adenocarcinoma of the uterine tube: Potential for lymph node metastases. Am J Obstet Gynecol 141:132–137
Author information
Authors and Affiliations
Additional information
In cooperation with: C. Altmutter, G. Bartussek, M. Bayr, A. Bichler, L. Fuith, W. Grünberger, K. Kahn, S. Karasegh, H. Krahuletz, L. Leodeolter, M. Medl, H. Salzer, A. Schröck, M. Stiglbauer, S. Szalay, R. Taschner, A. Wellenhofer, N. Wirrani, G. Wolfram
Rights and permissions
About this article
Cite this article
Klein, M., Rosen, A., Lahousen, M. et al. Evaluation of adjuvant therapy after surgery for primary carcinoma of the Fallopian tube. Arch Gynecol Obstet 255, 19–24 (1994). https://doi.org/10.1007/BF02390670
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02390670