Abstract
Report of two new pediatric cases of pulmonary alveolar microlithiasis (PAM). PAM is a rare disease of unknown etiology; not more than 38 cases have been reported aged less than 18 years. The essential features of this disease are (1) a characteristic radiographic appearance of a sand-like opacity of both lungs and linear densities like “beads on a string» along the heart, pleura and interlobar fissures; this is best visualized by fluoroscopy in combination with magnification technique; (2) extremely few clinical signs and almost no laboratory abnormalities.
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References
Harbitz F (1918) Extensive calcification of lungs as distinct disease. Arch Int Med 21: 139
Puhr L (1933) Microlithiasis alveolaris pulmonum. Virch Arch 290: 156
Lindig W (1951) Ein klinisch-röntgenologischer Beitrag zum Krankheitsbild der „Mikrolithiasis alveolaris pulmonum“. ROFO 75: 678
Sosman MC, Dodd GD, Jones WD, Pillmore GU (1957) The familial occurrence of pulmonary alveolar microlithiasis. AJR 77: 947
Brown ML, Swee RG, Olson RJ, Bender CE (1978) Pulmonary uptake of 99 m technetium diphosphonate in alveolar microlithiasis AJR 131: 703
Schildknecht O (1932) Zur Pathogenese verkalkter Schichtungskugeln sog. „Corpora amylasea“, in der Lunge (unter Mitteilung eines ungewöhnlichen Falles). Arch Pathol Anat 285: 466
Caffrey PR, Altmann RS (1965) Pulmonary alveolar microlithiasis occuring in premature twins. J Pediatr 66: 758
Kent G, Gilbert ES, Meyer HH (1955) Pulmonary microlithiasis AMA Arch Pathol 60: 556
Burguet W, Reginster A (1967) L'hérédité de la microlithiase alveolaire pulmonaire. A propos d'une nouvelle observation familiale. Ann Genet (Paris) 10: 75
Rotem Y, Solomon M, Hertz-Frankenhuis M (1963) Microlithiase des alvéoles pulmonaires. Ann Paediatr 201: 4
Cole WR (1959) Pulmonary alveolar microlithiasis J Fac Radiol 10: 54
Geubelle F, Lambrechts A, Chantraine JM, Lambrechts L (1971) Pulmonary alveolar microlithiasis: an intestinal (inborn) error? Acta Paediatr Belg 25: 69
Foote EL (1957) Microlithiasis alveolaris pulmonum: a case report. J Maine MA 48: 230
Balikian JP, Fuleihan FJD, Nucho CN (1968) Pulmonary alveolar microlithiasis: report of five cases with special reference to roentgen manifestations. AJR 103: 509
Caffarelli, de G (1976) La microlithiasis alvéolaire pulmonaire. A propos d'un cas découvert à l'âge de 30 mois. Thesis. Reims
Chetty A, Paul VK, Kumar A, Mitra DK, Chopra P (1983) Alveolar microlithiasis — a case report with review of literature Indian J Pediatr 50: 453
Clark RB, Johnson FG (1961) Idiopathic pulmonary alveolar microlithiasis: A case report and brief review of the literature Pediatrics 28: 650
De Maestrì A, Lojodice G (1961) Microlitiasi endoalveolare polmonare in un bambino di 7 anni. Minerva Pediatr 13: 890
Ehsani H, Neufang KFR (1981) Microlithiasis alveolaris pulmonum-Bericht über zwei Beobachtungen. Röntgenblatter 34: 51
Freour P, Laumonnier P, Verger P, Germouty R, Cardinaud P, Cardinaud JP (1959) Les microlithiases pulmonaires alvéolaires: à propos de deux cas familiaux de miliaires calcifiées. J Med Bordeaux 136: 459
Greenberg MJ (1957) Miliary shadows in the lungs due to microlithiasis alveolaris pulmonum. Thorax 12: 171
Herrault A, Gerbeaux J, Grunberg J, Gaultier C, Boccon-Gibod L, Tournier G (1972) Microlithiase alvéolaire. A propos d'un cas découvert à l'âge de 11 ans. Ann Pediatr 19: 599
Hirota S (1955) Microlithiasis alveolaris pulmonum. Nippon Rinsho Kekkaku 14: 834
Israel-Asselain R, Chebat J, Abelanet R, Lechien J (1960) Microlithiase alvéolaire pulmonaire démontrée par biopsie J Fr Med Chir Thor 14: 635
Manz A (1954) Mikrolithiasis der Lungen mit Pilzbefall. Beitr. Klin Tuberk 3: 598
Mikhailov V (1952) Pulmolithiasis endalveolaris et interstitialis diffusa. Klin Med (Mosk) 32: 31
Petranyi G, Zsebők Z (1954) Mikrolithiasis alveolaris miliaris pulmonum. Radiol Clin (Basel) 23: 202
Ribo JL, Canps F, Barnadas N, Manzanares R, Medina M (1985) Microlitiasis alveolar pulmonar. Radiologia (Madrid) 27: 27
Saputo V, Zocchi M, Mancosu M, Bonaldi U, Croce P (1979) Pulmonary alveolar microlithiasis. A case report with a discussion of differential diagnosis. Helv Paediatr Acta 34: 245
Sato K (1955) Three cases of microlithiasis alveolaris pulmonum occurring in one family. Sci Rep Res Inst Tohoku Univ [Med] 6: 391
Semelaigne G, Hurez A, Le Braz A (1958) Images micronodulaires pulmonaires familiales. Microlithiase alvéolaire diffuse très probable. Arch Fr Pediatr 15: 670
Takahashi YA (1954) Case report of microlithiasis alveolaris pulmonum. Nippon Rinsho Kekkaku 12: 89
Thind GS, Bhatia JL (1978) Pulmonary alveolar microlithiasis Br J Dis Chest 72: 151
Toshiya K, Yukinobu K, Shusuke T (1972) Pulmonary alveolar microlithiasis. Am Rev Respir Dis 105: 105
Varma BN (1963) Pulmonary alveolar microlithiasis in a child of 13 years. Br J Dis Chest 57: 213
Verger P, Laigle JL, Guillard JM, Revelmouroz H, Leger H (1973) Microlithiase alvéolaire pulmonaire. Une nouvelle observation chez une fillette de 12 ans. Rev Pediatr 9: 653
Yang SP, Lin CC (1963) Pulmonary alveolar microlithiasis. A report of two youngest cases in a family. Dis Chest 44: 163
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Volle, E., Kaufmann, H.J. Pulmonary alveolar microlithiasis in pediatric patients — review of the world literature and two new observations. Pediatr Radiol 17, 439–442 (1987). https://doi.org/10.1007/BF02388272
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DOI: https://doi.org/10.1007/BF02388272