Abstract
Patients with osteoporosis from 228 medical institutions throughout Japan were randomly divided into 2 groups; Group A (control group) received no treatment and Group B (the treated group) was given 1α-hydroxy-vitamin D3 1µg daily. Radiography of the thoracic and lumbar spines in the patients were taken before and after one year's study. The two groups were homogeneous as to age and severity of osteoporosis. The incidence of vertebral fractures was only calculated in female patients who comprised the major part of each group (named “Group A'” and “B'” respectively).
The incidence of vertebral fractures in 311 female patients in Group A was 759 fractures/1,000 patient·years and in the 355 female patients in Group B was 411/1,000 patient·years. The incidence of fractures increased with advancing age and bone loss in Group A', but did not in Group B'. From this study, it has been clarified that 1α-hydroxy-vitamin D3 can lower the incidence of vertebral fractures caused by decreasing bone loss.
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Hayashi, Y., Fujita, T. & Inoue, T. Decrease of vertebral fracture in osteoporotics by administration of 1α-hydroxy-vitamin D3 . J Bone Miner Metab 10, 50–54 (1992). https://doi.org/10.1007/BF02378983
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DOI: https://doi.org/10.1007/BF02378983