Abstract
Three cases of Castleman's disease (CD) of the abdomen and pelvis are reported. Tumoral lesions were located in the lymph nodes of the head of the pancreas, the gastropancreatic fold, and around the left iliac artery. Histologically, all the tumoral leasions demonstrated the hyalinevascular type of CD. This unusual presentation made CD difficult to diagnose preoperatively, since these lesions more closely resembled malignant tumors on computed tomography and angiography. We discuss the problems of diagnosing and classifying CD, together with a review of the literature.
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Castleman B, Iverson L, Menendez P. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956;9:822–830.
Saltzstein SL. Pulmonary malignant lymphomas and pseudolymphomas: Classification, therapy, and prognosis. Cancer 1963;16:928–955.
Timme AH. Angiofollicular hyperplasia of an abdominal lymph node. S Afr Med J 1965;39:356–358.
Kahn LB, Ranchod M, Stables DP, et al. Giant lymph node hyperplasia with hematological abnormalities. S Afr Med J 1973;47:811–816.
Humpherys SR, Holley KE, Smith LH, et al. Mesenteric angiofollicular lymph node hyperplasia (lymphoid hamartoma) with nephrotic syndrome. Mayo Clin Proc 1975;50:317–321.
Miller JS, Miller JJ. Benign giant lymph node hyperplasia presenting as fever of unknown origin. J Pediatr 1975;87:237–239.
Garcia-SanMiguel J, Rozman C, Palacin A, et al. Mesenteric hyaline plasma cell lymph node hyperplasia with amyloid deposits. Arch Intern Med 1981;141:261–263.
Iida E, Kohno A, Mikami T, et al. Mesenteric Castleman tumor. J Comput Assist Tomogr 1983;7:338–340.
Bjarnason I, Cotes PM, Knowles S, et al. Giant lymph node hyperplasia (Castleman's disease) of the mesentery. Gastroenterology 1984;87:216–223.
Powell RW, Lightsey AL, Thomas WJ, et al. Castleman's disease in children. J Pediatr Surg 1986;21:678–682.
Ferreirós J, León NG, Mata MI, et al. Computed tomography in abdominal Castleman's disease. J Comput Assist Tomogr 1989;13:433–436.
Garber SJ, Shaw DG. Case report: The ultrasound and computed tomography appearance of mesenteric Castleman disease. Clin Radiol 1991;43:429–430.
Hung I-J, Kuo T-T, Lin J-N. New observations in a child with angiofollicular lymph node hyperplasia (Castleman's disease) originated from the mesenteric root. Am J Pediatr Hematol/Oncol 1992;14:255–260.
Tung KSK, McCormack LJ. Angiomatous lymphoid hamartoma. Report of five cases with a review of the literature. Cancer 1967;20:525–536.
Buchanan GR, Chipamn JJ, Hamilton BL, et al. Angiomatous lymphoid hamartoma: Inhibitory effects on erythropoiesis, growth, and primary hemostasis. J Pediatr 1981;99:382–388.
Joseph N, Vogelzang RL, Hidvegi D, et al. Computed tomography of retroperitoneal Castleman disease (plasma cell type) with sonographic and angiographic correlation. J Comput Assist Tomogr 1985;9:570–572.
Gerald W, Kostianovsky M, Rosai J. Development of vascular neoplasia in Castleman's disease. Am J Surg Pathol 1990;14:603–614.
Castleman B, Towne VW, Editor. Case records of the Massachusetts General Hospital. Case 40011. N Engl J Med 1954;250:26–30.
Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972;25670–683.
Tsukamoto N, Iraha H, Matsuyama T, et al. Giant lymph node hyperplasia. Report of two interesting cases. Gynecol Oncol 1980;9:394–404.
Martin JME, Bell B, Ruether BA. Giant lymph node hyperplasia (Castleman's disease) or hyaline vascular type. A J C P 1985;84:439–446.
Neerhout RC, Larson W, Mansur P. Mesenteric lymphoid hamartoma associated with chronic hypoferremia, anemia, growth failure and hyperglobulinemia. N Engl J Med 1969;280:922–925.
Burgert EO, Gilchrist GS, Fairbanks VF, et al. Intraabdominal, angiofollicular lymph node hyperplasia (plasma-cell variant) with an antierythropoietic factor. Mayo Clin Proc 1975;50:542–546.
Symmers D. Primary hemangiolymphoma of the hemal nodes: An unusual variety of malignant tumor. Arch Intern Med 1921;28:467–474.
Lattes R, Pachter MR. Benign lymphoid masses of probable hamartomatous nature. Cancer 1962;15:197–214.
Daley M, Cornog JL. Pelvic retroperitoneal lymphoid hamartoma. J Urol 1967;97:235–239.
Boxer LA, Boxer GJ, Flair RC, et al. Angiomatous lymphoid hamartoma associated with chronic anemia, hypoferremia, and hypergammaglobulinemia. J Pediatr 1972;81:66–70.
Emson HE. Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis. Cancer 1973;31:241–245.
Riba PO. Castleman's disease. Angiofollicular benign lymph node hyperplasia. Radiological features in the differential diagnosis of vascular tumours of the pelvis. Br J Radiol 1979;52:412–414.
Lepke RA, Pagani JJ. Pancreatic Castleman disease simulating pancreatic carcinoma on computed tomography. J Comput Assist Tomogr 1982;6:1193–1195.
Yebra M, Vargas JA, Menéndez MJ, et al. Gastric Castleman's disease with a Lupus-like circulating anticoagulant. Am J Gastroenterol 1989;84:566–570.
Flendrig JA. Benign giant lymphoma: Clinicopathologic correlation study. The year book of cancer. Chicago: Year Book Medical 1970;296–299.
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Kiguchi, H., Ishii, T., Ishikawa, Y. et al. Castleman's disease of the abdomen and pelvis: Report of three cases and a review of the literature. J Gastroenterol 30, 661–666 (1995). https://doi.org/10.1007/BF02367795
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DOI: https://doi.org/10.1007/BF02367795