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A microcomputer based automated, quantitative coronary angiographic analysis system

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Abstract

Rapid and accurate assessment of coronary artery stenotic severity is important in therapy and understanding of coronary artery disease. Since automated systems minimize prejudiceand variations in analysis, we developed an automated, quantitative coronary analysis system utilizing an IBM PC-XT computer. Film images (35 mm) were cine-to-video converted and subsequently digitized by an IBM PC-XT computer. Given an approximate center line, the computer automatically detected edges, corrected for X-ray magnification, and calculated arterial dimensions. On objects of known dimensional sizes, the correlation coefficient between actual and calculated dimensions was 0.996 (p<0.01) with a standard error of estimate of 0.07 mm and ±3.0% reproducibility. For objects less than 1 mm in diameter, the standard error of estimate was 0.05 mm with ±4.1% reproducibility. However, with minimal contrast material (25%), the standard error of estimate increased to 0.20 mm with ±7.2% reproducibility. The results indicate that automated, quantitative coronary angiography can be achieved using an inexpensive IBM PC-XT based system, provided that the vessels are adequately opacified.

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Authors and Affiliations

  1. Section of Cardiology Bowman Gray School of Medicine, Wake Forest University, 300 South Hawthorne Road, 27103, Winston-Salem, NC

    William P. Santamore Ph.D., Frederic R. Kahl, Michael A. Kutcher, Michael Negin, James L. Whiteman, Jeffrey P. Kase & William C. Little

  2. Mnemonics, Incorporated, Mount Laurel, NJ

    William P. Santamore Ph.D., Frederic R. Kahl, Michael A. Kutcher, Michael Negin, James L. Whiteman, Jeffrey P. Kase & William C. Little

Authors
  1. William P. Santamore Ph.D.
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  2. Frederic R. Kahl
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  3. Michael A. Kutcher
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  4. Michael Negin
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  5. James L. Whiteman
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  6. Jeffrey P. Kase
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  7. William C. Little
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Additional information

This study was supported in part by NIH Grant Number HL 36051. Dr. Little is an established investigator of the American Heart Association.

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Santamore, W.P., Kahl, F.R., Kutcher, M.A. et al. A microcomputer based automated, quantitative coronary angiographic analysis system. Annals of Biomedical Engineering 16, 367–377 (1988). https://doi.org/10.1007/BF02364624

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  • DOI: https://doi.org/10.1007/BF02364624

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