Abstract
The investigation was devoted to the role of the synthesis of protein and peptide factors during the formation of chemosensory memory in rats. Two models of gustatory memorization were used: conditioned taste aversion (CTA), induced by the association of the taste of saccharine with a toxic injection of lithium chloride, and enhanced taste preference (ETP), induced by the influence of preliminary drinking of a saccharine solution on its repeat consumption. It was found that, under conditions of the inhibition of protein synthesis in the brain of 43% by cycloheximide and of 59% by 8-azaguanine. CTA does not form. ETP does not form under the influence of cycloheximide, but not [sic] of 8-azaguanine. A hypothesis was advanced regarding the participation of a varied spectrum of protein and peptide substances in the formation of taste aversion and preference. An influence of protein synthesis blockers on the process of retrieval of gustatory memory was not found.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. V. Anokhin, “Early Genes,” in: The Mechanisms of Learning and Memory [in Russian], NIINF im. P. K. Anokhina RAMN, Moscow (1992).
I. P. Ashmarin and L. A. Klyucharev, Protein Synthesis Inhibitors [in Russian], Meditsina, Leningrad (1975).
G. A. Vartanyan and M. N. Lokhov, The Problem of Memory Transport. Mechanisms of Memory [in Russian], Nauka, Leningrad (1987).
V. G. Kassil, Alimentary Behavior in Ontogenesis [in Russian], Nauka, Leningrad (1990).
G. F. Lakin, Biometry [in Russian], Vyssh. Shk., Moscow (1990).
O. N. Serova, Gustatory Afferentation in the Systemic Mechanisms of the Regulation of the Ingestion of Food and the Realization of Specialized Appetites [in Russian], NIINF im. P. K. Anokhima RAMN, Moscow (1992).
K. V. Sudakov, “Systemic functions of the brain under the conditions of the action of blockers of the synthesis of protein and oligopeptides,” Vestn. RAMN, No. 7, 40 (1992).
S. K. Sudakov, “The molecular mechanisms of memory in the systemic organization of behavioral acts,” in: The Functional Systems of the Organism [in Russian], Meditsina, Moscow (1987), p. 166.
A. V. Tokarev, E. O. Pernova, and Yu. V. Balabanov, “The chemical nature of the factor of reflex taste aversion,” Byul. Éksp. Biol. i Med., No. 1, 10 (1983).
R. Norgren, “The gustatory system in mammals,” Am. J. Otolaryngol.,4, 234 (1983).
I. Ramirez, “Why do sugars taste good?” Neurosci. and Biobehav. Rev.,14, 125 (1990).
A. R. Tucker and T. P. S. Oei, “Protein synthesis inhibition and amnesia for saccharin aversion memory in rats after intracisternal administration of cycloheximide,” Physiol. and Behav.,28, 1025 (1982).
Additional information
P K. Anokhin Research Institute of Normal Physiology. Russian Academy of Medical Sciences, Moscow. Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 45, No. 4, pp. 742–747, July–August, 1995.
Rights and permissions
About this article
Cite this article
Serova, O.N., Solov'ea, N.A., Lagutina, L.V. et al. Formation of taste aversion and preference in protein synthesis inhibition in rats. Neurosci Behav Physiol 26, 477–481 (1996). https://doi.org/10.1007/BF02359410
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02359410