Summary
Effects of local single irradiation on lung metastasis of VX2 carcinoma transplanted in maxillary sinus of rabbits were evaluated. When an inadequate irradiation for complete regression was given, the rate of pulmonary metastases in irradiated groups was remarkably increased compared with non-irradiated one, although tumor growths in irradiated ones were apt to be inhibited corresponding to the given dose. Three parameters detected in the study related to general conditions were not so significantly different among the groups although those in irradiated groups were apt to be worse than those in control. Histologically most remarkable difference between in control and irradiated groups was stromal respose. However, on the question of whether stromal response could react as a diffensive or promotive mechanisms against tumor metastases, further studies would be needed including analysis of infiltrative cells.
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Kaplan, H. S., Murphy, E. D.: The effect of local roentgen irradiation on the biological behavior of a transplantable mouse carcinoma. Increased frequency of pulmonary metastasis.J. Nat. Cancer Inst. 9: 407–413, 1949.
Yamamoto, T.: Experimental study on effect of X-ray on metastasis of malignant tumor, especially in bones.Jap. J. Obst. Gynec 19: 559–569, 1936.
Fisher, E. R., Fisher, B.: Effect of X-irradiaiation on parameters of tumor growth, histology and ultrastructure.Cancer 24: 39–55, 1969.
Suit, H. D., Sedlacek, R. S., Gilette, E. L.: Examination for a correlation between probabilities of development of distant metastasis and of local recurrence.Radiology 95: 189–194, 1970.
Crile, G. Jr., Deodhar, S. D.: Role of preoperative irradiation in prolonging concomitant immunity and preventing metastasis in mice.Cancer 27: 629–634, 1971.
Van den Brenk, H A. S., Sharpington, C.: Effect of local X-irradiation of a primary sarcoma in the rat on dissemination and growth of metastasis: Dose-response characteristics.Br. J. Cancer 25: 812–830, 1971.
Sheldon, P. W., Begg, A. C., Fowler, J. F., Lansley, I. F.: The incidence of lung metastases in C3H mice after treatment of implanted solid tumors with X-rays or surgery.Br. J. Cancer 30: 342–348, 1974.
McCredie, J. A., Inch, W. R., Cowie, H. C.: Effect of excision or local radiotherapy to a tumor and its regional nodes on metastases.Cancer 31: 983–987, 1973.
Peters, L. J.: A study of the influcence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behavior.Br. J. Cancer 32: 355–365, 1975.
Tsubakimoto, M.: Studies on fibrinolysis and coagulation with the spread of metastases of VX 2 carcinoma transplanted into maxillary sinus of the rabbit.J. Osaka Univ. Dent. Sch. 19: 6–18, 1974.
Van den Brenk, H. A. S., Moore, V., Sharpington, C., Orton, C.: Production of metastases by a primary tumor irradiated under aerobic and anaerobic conditions in vivo.Br. J. Cancer 26: 402–412, 1972.
Sheldon, P.: The effect of irradiating a transplanted solid sarcoma on the subsequent development of metastases.Br. J. Cancer 30: 416–420, 1974.
Okamoto, Y.: Stromal response in relation to invading forms of tumors: A histochemical and histopathological study.Gann 57: 563–576, 1966.
Black, J. W.: The localization of metastatic Brown-Pearce carcinoma in granulation tissue.Br. J. Cancer 18: 143–145, 1964.
Rosenau, W., Moon, H. D.: Lysis of homologous cells by sensitized lymphocytes in tissue culture.J. Nat. Cancer Inst. 27: 471–483, 1961.
Grundmann, E., Vollmer, E.: Early local reaction and lymphnode permeation of rat carcinoma HH 9-cl 14 Cells. An immunological approach.Path Res Pract 178: 304–309, 1985.
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Matsumura, T., Sugahara, T., Yui, S. et al. Effect of irradiation on lung metastasis of VX2 carcinoma in maxillary sinus of rabbit. Oral Radiol. 1, 11–17 (1985). https://doi.org/10.1007/BF02350164
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DOI: https://doi.org/10.1007/BF02350164