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Detection of autonomic modulation in permanent atrial fibrillation

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Abstract

A new signal processing method for the detection of cyclic variations in atrial fibrillation frequency is presented. The objective was to investigate whether or not respiration, through the autonomic nervous system, modulates the fibrillation frequency in patients with permanent atrial fibrillation. A group of eight patients with permanent atrial fibrillation, atrioventricular block III and a permanent pacemaker were studied during rest, rhythm-controlled respiration, with each breath lasting for 8s (i.e. a breathing frequency of 0.125 Hz), and rhythm-controlled respiration after full vagal blockade by atropine. Using the new method, a spectral peak could be detected, in two of the patients, at the breathing frequency during rhythm-controlled respiration then disappeared after injection of atropine.

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References

  • Akselrod, S. (1995): ‘Components of heart rate variability: basic studies’, inMalik, M., andCamm, A. J. (Eds.): Heart rate variability, chap. 12 (Futura Publishing, 1995), pp. 147–163

  • Akselrod, S., Gordon, D., Ubel, F. A., Shannon, D. C., andBargar, A. C. (1981): ‘Power spectral analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control’,Science,213, pp. 220–222

    Google Scholar 

  • Bollmann, A., Kanuru, N., McTeague, K., Walter, P., DeLurgio, D., andLangberg, J. (1998): ‘Frequency analysis of human atrial fibrillation using the surface electrocardiogram and its response to ibutilide’,Am. J. Cardiol.,81, pp. 1439–1445

    Article  Google Scholar 

  • Bollmann, A., Mende, M., Neugebauer, A., andPfeiffer, D. (2002): ‘Atrial fibrillatory frequency predicts atrial defibrillation threshold and early arrhythmia recurrence in patients undergoing internal cardioversion of persistent atrial fibrillation’,Pacing Clin. Electrophysiol.,25, pp. 1179–1184

    Article  Google Scholar 

  • Holm, M., Pehrsson, S., Ingemansson, M., Sörnmo, L., Johansson, R., Sandhall, L., Sunemark, M., Smideberg, B., Olsson, C., andOlsson, B. (1998): ‘Non-invasive assessment of atrial refractoriness during atrial fibrillation in man—introducing, validating and illustrating a new ECG method’,Cardiovasc. Res.,38, pp. 69–81

    Article  Google Scholar 

  • Kim, K. B., Rodefeld, M. D., Schuessler, R. B., Cox, J. L., andBoineau, J. P. (1996): ‘Relationship between local atrial fibrillation interval and refractory period in the isolated canine atrium’,Heart,94, pp. 2961–2967

    Google Scholar 

  • Lammers, W., Allessie, M., Rensma, P., andSchalij, M. (1986): ‘The use of cycle length to determine spatial dispersion in electrophysiological properties and to characterize the underlying mechanism of fibrillation’,New Trends Arrhythmias,II

  • Langley, P., Bourke, J. P., andMurray, A. (2000): ‘Frequency analysis of atrial fibrillation’.Proc. Computers in Cardiology, IEEE Computer Society, pp. 65–68

  • Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., andFurlan, R. (1986): ‘Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and concious dog’,Circ. Res.,59, pp. 178–193

    Google Scholar 

  • Parzen, E. (1963): ‘On spectral analysis with missing observations and amplitude modulation’,Sankya A,25, pp. 383–392

    MATH  MathSciNet  Google Scholar 

  • Rieta, J. J., Zarzoso, V., Millet Roig, J., Garcia Civera, R., andRuiz Granell, R. (2000): ‘Atrial activity extraction based on blind source separation as an alternative QRST cancellation for atrial fibrillation analysis’.Proc. Computers in Cardiology, IEEE Computer Society, pp. 69–72

  • Rosen, Y., andPorat, B. (1989): ‘The second-order moments of sample covariances for time series with missing observations’,IEEE Trans. Inform. Theory,35, pp. 334–341

    MathSciNet  Google Scholar 

  • Stridh, M., andSörnmo, L. (2001): ‘Spatiotemporal QRST cancellation techniques for analysis of atrial fibrillation’,IEEE Trans. Biomed. Eng.,48, pp. 105–111

    Google Scholar 

  • Stridh, M., Sörnmo, L., Meurling, C. J., andOlsson, S. B. (2001): ‘Characterization of atrial fibrillation using the surface ECG: time-dependent spectral properties’,IEEE Trans. Biomed. Eng.,48, pp. 19–27

    Google Scholar 

  • Stridh, M., Sörnmo, L., Meurling, C. J., andOlsson, S. B. (2003): ‘Sequential characterization of atrial tachyarrhythmias based on ECG time-frequency analysis’,IEEE Trans. Biomed. Eng. (in press)

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Authors and Affiliations

  1. Signal Processing Group, Department of Electrical Engineering, Lund University, Lund, Sweden

    M. Stridh & L. Sörnmo

  2. Department of Cardiology, Lund University, Lund, Sweden

    C. Meurling & B. Olsson

Authors
  1. M. Stridh
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  2. C. Meurling
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  3. B. Olsson
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  4. L. Sörnmo
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Correspondence to M. Stridh.

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Stridh, M., Meurling, C., Olsson, B. et al. Detection of autonomic modulation in permanent atrial fibrillation. Med. Biol. Eng. Comput. 41, 625–629 (2003). https://doi.org/10.1007/BF02349969

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  • DOI: https://doi.org/10.1007/BF02349969

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