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Colonic mucosal hemodynamics and tissue oxygenation in patients with ulcerative colitis: Investigation by organ reflectance spectrophotometry

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Abstract

Colonic mucosal hemodynamics were investigated at the rectosigmoidal region of the colon in 46 patients with ulcerative colitis and in 18 normal subjects by organ reflectance spectrophotometry under colonoscopy. The value for the index of mucosal hemoglobin concentration (IHb) was significantly higher, and value for the index of mucosal hemoglobin oxygen saturation (ISO2) was significantly lower in patients with active ulcerative colitis than values in the normal controls or in patients with inactive ulcerative colitis. The results indicate mucosal congestion and hypoxemia in patients with active ulcerative colitis. The changes in IHb and ISO2 correlated well with the severity of ulcerative colitis scored by endoscopic findings and with the number of infiltrating inflammatory cells in the mucosa analyzed histologically in biopsy samples. In conclusion, the colonic mucosal microcirculation in patients with active ulcerative colitis was disturbed and showed congestion and hypoxemia. The analysis of hemodynamic changes may be helpful for assessing the activity of ulcerative colitis.

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Authors and Affiliations

  1. First Department of Medicine, Osaka University School of Medicine, 2-2 Yamada-oka, 565, Suita, Japan

    Masahiko Tsujij, Sunao Kawano, Shingo Tsuji, Ichizo Kobayashi, Yoshiyuki Takei, Kouichi Nagano, Hideyuki Fusamoto & Takenobu Kamada

  2. Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Tatsuo Ogihara & Nobuhiro Sato

Authors
  1. Masahiko Tsujij
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  2. Sunao Kawano
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  3. Shingo Tsuji
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  4. Ichizo Kobayashi
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  5. Yoshiyuki Takei
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  6. Kouichi Nagano
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  7. Hideyuki Fusamoto
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  8. Takenobu Kamada
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  9. Tatsuo Ogihara
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  10. Nobuhiro Sato
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Tsujij, M., Kawano, S., Tsuji, S. et al. Colonic mucosal hemodynamics and tissue oxygenation in patients with ulcerative colitis: Investigation by organ reflectance spectrophotometry. J Gastroenterol 30, 183–188 (1995). https://doi.org/10.1007/BF02348663

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  • DOI: https://doi.org/10.1007/BF02348663

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