Skip to main content
Log in

Identification of the breast boundary in mammograms using active contour models

  • Published:
Medical and Biological Engineering and Computing Aims and scope Submit manuscript

Abstract

A method for the identification of the breast boundary in mammograms is presented. The method can be used in the preprocessing stage of a system for computeraided diagnosis (CAD) of breast cancer and also in the reduction of image file size in picture archiving and communication system applications. The method started with modification of the contrast of the original image. A binarisation procedure was then applied to the image, and the chain-code algorithm was used to find an approximate breast contour. Finally, the identification of the true breast boundary was performed by using the approximate contour as the input to an active contour model algorithm specially tailored for this purpose. After demarcation of the breast boundary, all artifacts outside the breast region were eliminated. The method was applied to 84 medio-lateral oblique mammograms from the Mini-MIAS database. Evaluation of the detected breast boundary was performed based upon the percentage of false-positive and false-negative pixels determined by a quantitative comparison between the contours identified by a radiologist and those identified by the proposed method. The average false positive and false negative rates were 0.41% and 0.58%, respectively. The two radiologists who evaluated the results considered the segmentation results to be acceptable for CAD purposes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bick, U., Giger, M. L., Schmidt, R. A., Nishikawa, R. M., Wolverton, D. E., andDoi, K. (1995): ‘Automated segmentation of digitized mammograms’,Acad. Radiol.,2, pp. 1–9

    Article  Google Scholar 

  • Bick, U., Giger, M. L., Schmidt, R. A., Nishikawa, R. M., andDoi, K. (1996): ‘Density correction of peripheral breast tissue on digital mammograms’,Radio Graphics,16, pp. 1403–1411

    Google Scholar 

  • Byng, J. W., Critten, J. P., andYaffe, M. J. (1997): ‘Thickness-equalization processing for mammographic images’,Radiology,203, pp. 564–568

    Google Scholar 

  • Chandrasekhar, R., andAttikiouzel, Y. (1997): ‘A simple method for automatically locating the nipple on mammograms’,IEEE Trans. Med. Imag.,16, pp. 483–494

    Google Scholar 

  • Ferrari, R. J., Rangayyan, R. M., Desautels, J. E. L., andFrère, A. F. (2000): ‘Segmentation of mammograms: identification of the skin-air boundary, pectoral muscle, and fibro-glandular disc’, inYaffe, M. J. (Ed.): ‘Proc. 5th Int. workshop on digital mammography’ Toronto, ON, Canada, pp. 573–579

  • Ferrari, R. J., Rangayyan, R. M., Desautels, J. E. L., andFrère, A. F. (2001): ‘Analysis of asymmetry in mammograms via directional filtering with Gabor wavelets’,IEEE Trans. Med. Imag.,20, pp. 953–964

    Google Scholar 

  • Gonzalez, R. C., andWoods, R. E. (1992): ‘Digital image processing’, (Addison-Wesley, Reading, MA, 1992)

    Google Scholar 

  • Kass, M., Witkin, A., andTerzopoulos, D., (1988): ‘Snakes: active contour models,Int. J. Comput. Vis.,1, pp. 321–331

    Google Scholar 

  • Lau, T. K., andBischof, W. F. (1991): ‘Automated detection of breast tumors using the asymmetry approach’,Comput. Biomed. Res.,24, pp. 273–295

    Article  Google Scholar 

  • Lloyd, S. (1982): ‘Least squares quantization in PCM’,IEEE Trans. Inf. Theory,28, pp. 129–137

    Article  MATH  MathSciNet  Google Scholar 

  • Lobregt, S., andViergever, M. A. (1995): ‘A discrete dynamic contour model’,IEEE Trans. Med. Imag.,14, pp. 12–24

    Google Scholar 

  • Lou, S. L., Lin, H. D., Lin, K. P., andHoogstrate, D. (2000): ‘Automatic breast region extraction from digital mammograms for PACS and telemammography applications’,Comput. Med. Imag. Graph.,24, pp. 205–220

    Article  Google Scholar 

  • Mackiewich, B. (1995): ‘Intracranial boundary detection and radio frequency correction in magnetic resonance images’. Master’s thesis, School of Computing Science, Simon Fraser University, Burnaby, B.C., Canada, August 1995

    Google Scholar 

  • Mattis, P., andKimball, S. ‘GIMP: GNU Image Manipulation Program’, version 1.1.17. http://www.gimp.org, GNU General Public License, GPL

  • Méndez, A. J., Tahoces, P. G., Lado, M. J., Souto, M., Correa, J. L., andVidal, J. J. (1996): ‘Automatic detection of breast border and nipple in digital mammograms’,Comput. Methods Progr. Biomed.,49, pp. 253–262

    Google Scholar 

  • Miller, P., andAstley, S. (1993): ‘Automated detection of mammographic asymmetry using anatomical features’,Int. J. Pattern Recognit. Artif. Intell.,7, pp. 1461–1476

    Google Scholar 

  • Suckling, J., Parker, J., Dance, D. R., Astley, S., Hutt, I., Boggis, C. R. M., Ricketts, I., Stamatakis, E., Cerneaz, N., Kok, S. L., Taylor, P., Betal, D., andSavage, J. (1994): ‘The Mammographic Image Analysis Society digital mammogram database’, inGale, A. G., Astley, S. M., Dance, D. R., andCairns, A. Y. (Eds.): ‘Proc. 2nd Int. Workshop on Digital Mammography, vol. 1069 of Excerpta Medica International Congress Series’, York, England, pp. 375–378

  • Williams, D. J., andShah, M. (1992): ‘A fast algorithm for active contours and curvature estimation’,Comput. Vis. Graph. Image Process.: Image Underst.,55, pp. 14–26

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. M. Rangayyan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ferrari, R.J., Frère, A.F., Rangayyan, R.M. et al. Identification of the breast boundary in mammograms using active contour models. Med. Biol. Eng. Comput. 42, 201–208 (2004). https://doi.org/10.1007/BF02344632

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02344632

Keywords

Navigation