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Intraventricular interferon in a case of subacute sclerosing panencephalitis

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Abstract

a patient with subacute sclerosing panencephalitis (SSPE) was treated by direct administration of Interferon B into the cerebral ventricles. Immediately after the first dose intrathecal synthesis of IgG and the CNS antimeasles antibody titer fell significantly, only to rise again to the pretreatment levels 2 months after discontinuation of treatment. There was no improvement in the patient's clinical status.

Sommario

Viene descritto un caso di PESS trattato con Interferon B somministrato direttamente nei ventricoli cerebrali. Immediatamente dopo la prima somministrazione, l'indice della sintesi intratecale (CNS IgG SYN) e il livello liquorale degli anticorpi antimorbillo mostrarono un significativo decremento. Nel corso dei due mesi successivi i valori si riportarono ai livelli precedenti l'inizio della terapia. Un'azione antivirale solo iniziale e transitoria sembra essere stata innescata dalla terapia.

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Authors and Affiliations

  1. Istitato di Virologia, Università di Milano, Italy

    Mancuso R.

  2. Istituto Neurologico “C. Besta”, Via Celoria 11, 20133, Milano

    Boiardi A., Baldini S. M., Sghirlanzoni A. & Corridori F.

Authors
  1. Boiardi A.
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  2. Baldini S. M.
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  3. Sghirlanzoni A.
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  4. Mancuso R.
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  5. Corridori F.
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Boiardi, A., Baldini, S.M., Sghirlanzoni, A. et al. Intraventricular interferon in a case of subacute sclerosing panencephalitis. Ital J Neuro Sci 8, 277–281 (1987). https://doi.org/10.1007/BF02337487

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