Abstract
We present a clinical study of a patient aged 69 years with a clinical history of severe difficulty in walking and voluntary conjugate eye movement reduction in sideways glance and absence in vertical gaze. These symptoms led to diagnosis of Parkison disease and treatment with L-Dopa+anticholinergics drugs. The treatment with antiparkinsonian drugs was suspended and no change in his clinical condition resulted.
Methysergide therapy was initiated and the patient's response was monitored by video recording.
On the basis of our experience and the data reported in the literature we believe that methysergide therapy affords some relief of symptoms in patients suffering from PSP.
Sommario
Presentiamo uno studio clinico di un uomo di 69 anni con una storia clinica di notevole difficoltà nella deambulazione e di riduzione dei movimenti coniugati volontari oculari in lateralità e assenza di essi in verticalità. Questa sintomatologia ha portato alla diagnosi di morbo di Parkinson ed è stato iniziato un trattamento con L-DOPA e anticolinergici. Poi il trattamento è stato sospeso e non si è assistito a varianti della condizione clinica. È stato allora iniziato un trattamento con methysergide e la risposta alla cura è stata monitorizzata registrandola con videocssetta. Sulla base della nostra esperienza e dei dati riportati in letteratura rieniamo che il methysergide è in grado di ottenere miglioramenti nella sintomatologia della paralisi sopranucleare progressiva.
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Di Trapani, G., Stampatore, P., La Cara, A. et al. Treatment of progressive supranuclear palsy with methysergide. A clinical study. Ital J Neuro Sci 12, 157–161 (1991). https://doi.org/10.1007/BF02337027
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DOI: https://doi.org/10.1007/BF02337027