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Inhibitors of the angiotensin I converting enzyme as antihypertensive drugs

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Abstract

Inhibitors of the angiotensin I converting enzyme (captopril, enalapril) offer a new principle in the drug treatment of hypertension and congestive heart failure. The present survey deals with the mode of action of the converting enzyme inhibitors, including possible interference with the renin-angiotensin systems in the kidney, the vascular wall and the brain, with the kallikreine-bradykinine system and with the sympathetic nervous system, at both pre- and postjunctional sites. Furthermore, the haemodynamic pattern as well as the therapeutic applications are discussed, including the most important sideeffects, contra-indications, interactions and clinical pharmacokinetic properties.

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Authors and Affiliations

  1. Division of Pharmacotherapy, University of Amsterdam, Plantage Muidergracht 24, 1018, TV Amsterdam, The Netherlands

    P. A. van Zwieten, A. de Jonge & P. B. M. W. M. Timmermans

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  1. P. A. van Zwieten
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  2. A. de Jonge
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  3. P. B. M. W. M. Timmermans
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van Zwieten, P.A., de Jonge, A. & Timmermans, P.B.M.W.M. Inhibitors of the angiotensin I converting enzyme as antihypertensive drugs. Pharmaceutisch Weekblad Scientific Edition 5, 197–204 (1983). https://doi.org/10.1007/BF02332943

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