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Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis

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Summary

Seventy-eight patients, 40 suffering from cervical arthrosis and 38 from lumbar arthrosis, received for a period of two weeks paracetamol or a new preparation of glaphenine, in a double blind study. The two drugs were found to have the same efficiency on the subjective parameters but high bioavailability glaphenine seems to have an effectiveness in the range of articulatory movements, which is not found with paracetamol. The side effects were quite equivalent.

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References

  1. Peterfalvi, M., Branceni, D., Azadian-Boulanger, G., Chifflot, L., Jecquier, R. Etude pharmacologique d'un nouveau composé analgèsique anti-inflammatoire, la glafénine. Med Pharmacol Exp 1966, 15, 254–266.

    CAS  Google Scholar 

  2. Lithgow, D.M., Blecher, J. Controlled trial of glifanan and omnopon in postoperative pain. South Afr Med J 1971, 203–205.

  3. Van Staden, M.J. The use of glifanan in postoperative pain. South Afr Med J 1971, 1235–1237.

  4. Ruedy, J. A comparison of the analgesic effectiveness of glaphenine and standard oral analgesics in postoperative orthopedic patients. J Clin Pharmacol 1971, 11, 378–382.

    CAS  Google Scholar 

  5. Booy, R.H., Pijnbestrijding met éénvoudige analgetica in de tandheelkunde. Ned Tijdschr Tandheelkunde 1972, 79, 69–75.

    CAS  Google Scholar 

  6. Zelvelder, W.G., Douze, J., Pasmans, L.H., Phaf, C.W.R., Een dubbelblind vergelijkend onderzoek naar het effekt van enkele analgetica na kaakchirurgische ingrepen. Ned Tijdschr Tandheelkunde 1975, 82, 154–156.

    Google Scholar 

  7. Moolenaar, F., Stuurman-Bieze, A.G.G., Van Der Veen, W., Nijmeijer, J., Huizinga, T. Een vergelijkend onderzoek naar de resorptie en de biologische beschikbaarheid van glafenine na orale en rectale toediening.

  8. Vranckx, H. (Sopar S.A.) Composition pharmaceutique de glafénine. Brevet Belge no 896483 (1983).

  9. Lesne, M., Jaminet, F. Etude de la bioéquivalence de deux formes galéniques de glafénine chez l'homme sain. Personal communication (1982).

  10. Mayer, R. Etude de l'efficacité de comprimés de glafénine à haute biodisponibilité (G.H.B.) en stomatologie. Bulletin du Groupement International pour la recherche en sciences stomatologiques et odontologiques 1984, 27, 1–8.

    Google Scholar 

  11. Anderson, J.A. Separate sample logistic discrimination. Biometrika 1972, 59, 19–35.

    Google Scholar 

  12. Zerbe, G.O. Randomization analysis of the completely randomized design extended to growth and response curves. J Am Statistical Assoc 1979, 74, 215–221.

    Google Scholar 

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Choffray, D.U., Crielaard, J.M., Albert, A. et al. Comparative study of high bio-availability glaphenine and paracetamol in cervical and lumbar arthrosis. Clin Rheumatol 6, 518–525 (1987). https://doi.org/10.1007/BF02330588

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  • DOI: https://doi.org/10.1007/BF02330588

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