Summary
The major urinary metabolites of (+)-catechin (cyanidanol-3) in the rat were (+)-catechin glucuronide, 3′-O-methyl-(+)-catechin glucuronide and 3′-O-methyl-(+)-catechin sulphate. The latter conjugate was the major metabolite in marmoset urine.
Literatur
J. Kuhnau, Wld Rev. Nutr. Diet24, 117 (1975.
A. Bertelli, in: New Trends in the Therapy of Liver Diseases, p. 92. Ed. A. Bertelli. Karger, Basel 1975.
A.L. Blum, W. Doelle, K. Kortum, P. Peter, G. Strohmeyer, P. Berthet, H. Goebell, S. Pelloni, H. Poulsen and N. Tygstrup, Lancet2, 1153 (1977).
L.A. Griffiths, Biochem. J.92, 173 (1964).
N.P. Das and L.A. Griffiths, Biochem. J.115, 831 (1969).
I.C. Shaw and L.A. Griffiths, Xenobiotica10, 905 (1980).
S.P. James and P. Kestell, Xenobiotica8, 557 (1978).
A.M. Hackett and L.A. Griffiths, Drug Metab. Disposition9, 54 (1981).
G.C. Bolton and L.A. Griffiths, Drug Metab. Disposition7, 388 (1979).
H. G. Bray, W.V. Thorpe and K. White, Biochem. J.46, 271 (1950).
L.A. Griffiths and A. Barrow, Biochem. J.130, 1161 (1972).
L.A. Griffiths, A.M. Hackett, I.C. Shaw and S. Brown, in: Recent developments in mass spectrometry in biochemistry, medicine and environmental research, p. 9, Ed. A. Frigerio. Elsevier, Amsterdam 1981.
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Acknowledgment. The authors wish to thank Miss Rosemary Dring and Mr P.B. Wood for skilled technical assistance, Zyma S.A., Nyon, Switzerland, for financial support, and the Medical Research Council for a research studentship (to I.C.S.).
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Hackett, A.M., Shaw, I.C. & Griffiths, L.A. 3′-O-Methyl-(+)-catechin glucuronide and 3′-O-methyl-(+)-catechin sulphate: new urinary metabolites of (+)-catechin in the rat and the marmoset. Experientia 38, 538–540 (1982). https://doi.org/10.1007/BF02327037
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DOI: https://doi.org/10.1007/BF02327037