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Glutathione andγ -glutamyl cycle enzymes in rat mammary gland

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Summary

The main enzymes of theγ-glutamyl cycle during the lactogenic cycle in rat mammary gland were studied. A significant increase was found in all of them with the onset of lactogenesis. The effect of methionine sulfoximine on reduced glutathione concentration was studied in tissue slices of lactating mammary gland. The findings suggest that this compound affects glutathione synthesis by inhibitingγ-glutamylcysteine synthetase.

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Authors and Affiliations

  1. Departamento de Bioquímica, Facultad de Ciencias Básicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile

    J. Puente, E. Castellón & M. Sapag-Hagar

Authors
  1. J. Puente
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  2. E. Castellón
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  3. M. Sapag-Hagar
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Additional information

This work was supported by grant B1138-8223 from the Servicio de Desarrollo Cientifico, Universidad de Chile.

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Puente, J., Castellón, E. & Sapag-Hagar, M. Glutathione andγ -glutamyl cycle enzymes in rat mammary gland. Experientia 38, 531–532 (1982). https://doi.org/10.1007/BF02327032

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