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Vitamins K

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Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie

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Bibliography

  • Addinal, C. R.: Vitamins H, K and P. Merck Report46, 6 (1937).

    Google Scholar 

  • Almquist, H. J.: (1) Purification of the antihemorrhagic vitamin. J. of biol. Chem.114, 241 (1936).

    Google Scholar 

  • —: (2) Purification of the antihemorrhagic vitamin by distillation. J. of biol. Chem.115, 589 (1936).

    Google Scholar 

  • —: (1) Chemical and physical studies on the antihemorrhagic vitamin. J. of biol. Chem.117, 517 (1937).

    Google Scholar 

  • —: (2) Further studies on the antihemorrhagic vitamin. J. of biol. Chem.120, 635 (1937).

    Google Scholar 

  • —: (3) Crystals with vitamin K potency. Nature (Lond.)140, 25 (1937).

    Google Scholar 

  • —: (4) The antihemorrhagic vitamin. Poultry Sci.16, 166 (1937).

    Google Scholar 

  • — andA. A. Klose: (1) Antihemorrhagic activity of 2-methyl-1,4-naphthoquinione. J. of biol. Chem.130, 787 (1939).

    Google Scholar 

  • ——: (2) A derivative of vitamin K1 J. of biol. Chem.130, 791 (1939).

    Google Scholar 

  • ——: (3) Determination of the antihaemorrhagic vitamin. Biochemic. J.33, 1055 (1939).

    Google Scholar 

  • —— (4) The isolation of vitamin K as a choleic acid. J. amer. chem. Soc.61, 745 (1939).

    Google Scholar 

  • ——: (5) Color reactions in vitamin K concentrates. J. amer. chem. Soc.61, 1610 (1939).

    Google Scholar 

  • ——: (6) The antihemorrhagic activity of pure synthetic phthiocol. J. amer. chem. Soc.61, 1611 (1939).

    Google Scholar 

  • ——: (7) The antihemorrhagic activity of certain naphthoquinones. J. amer. chem. Soc.61, 1923 (1939).

    Google Scholar 

  • ——: (8) Synthetic and natural antihemorrhagic compounds. J. amer. chem. Soc.61, 2557 (1939).

    Google Scholar 

  • Almquist, H. J., E. Mecchi andA. A. Klose: Estimation of the antihaemorrhagic vitamin. Biochemic. J.32, 1897 (1938).

    Google Scholar 

  • —,C. F. Pentler andE. Mecchi: Synthesis of the antihemorrhagic vitamin by bacteria. Proc. Soc. exper. Biol. a. Med.38 336 (1938).

    Google Scholar 

  • —,E. L. R. Stokstad: (1) Dietary haemorrhagic disease in chicks. Nature (Lond.)136, 31 (1935).

    Google Scholar 

  • ——: (2) Hemorrhagic chick disease of dietary origin. J. of biol. Chem.111, 105 (1935).

    Google Scholar 

  • ——: Factors influencing the incidence of dietary hemorrhagic disease in chicks. J. Nutrit.12, 329 (1936).

    Google Scholar 

  • ——: Assay procedure for vitamin K (antihemorrhagic vitamin). J. Nutrit.14, 235 (1937).

    Google Scholar 

  • Anderson, R. J. andM. S. Newman: (1) The chemistry of the lipids of tubercle bacilli XXXIV. Isolation of a pigment and of anisic acid from the acetone-soluble fat of the human tubercle bacillus. J. of biol. Chem.101, 773 (1933).

    Google Scholar 

  • ——: (2) XXXV. The constitution of phthiocol, the pigment isolated from the human tubercle bacillus. J. of biol. Chem.103, 197 (1933).

    Google Scholar 

  • ——: (3) XXXVII. The synthesis of phthiocol, the pigment of the human tubercle bacillus. J. of biol. chem.103, 405 (1933).

    Google Scholar 

  • Andrus, W. De W., J. W. Lord, Jr. andR. A. Moore: The effect of hepatectomy on the plasma prothrombin and the utilization of vitamin K. Surgery6, 899 (1939).

    Google Scholar 

  • Ansbacher, S.: New observations on the vitamin K deficiency of the chick. Science (N.Y.)88, 221 (1938).

    Google Scholar 

  • —: A quantitative biological assay of vitamin K. J. Nutrit.17, 303 (1939).

    Google Scholar 

  • Ansbacher, S.: Vitamin K. Proc. amer. Soc. Biol.1940.

  • — andE. Fernholz: (1) Simple compounds with vitamin K activity. J. amer. chem. Soc.61, 1924 (1939).

    Google Scholar 

  • ——: (2) Vitamin K activity in the benzoquinone series. J. of biol. Chem.131, 399 (1939).

    Google Scholar 

  • —— andM. A. Dolliver: Vitamin K-active derivatives of 2-methyl-1,4-naphthoquinone. J. amer. chem. Soc.62, 155 (1940).

    Google Scholar 

  • —— andH. B. MacPhillamy: Vitamin K and synthetic vitamin K1. Proc. Soc. exper. Biol. a. Med.42, 655 (1939).

    Google Scholar 

  • Binkley, S. B., L. C. Cheney, W. F. Holcomb, R. W. McKee, S. A. Thayer, D. W. MacCorquodale andE. A. Doisy: The constitution and systhesis of vitamin K1. J. amer. chem. Soc.61, 2558 (1939).

    Google Scholar 

  • —,D. W. MacCorquodale, L. C. Cheney, S. A. Thayer, R. W. McKee andE. A. Doisy: Derivatives of vitamins K1 und K2. J. amer. chem. Soc.61 1612 (1939).

    Google Scholar 

  • —,D. W. MacCorquodale, S. A. Thayer andE. A. Doisy: The isolation of vitamin K1. J. of biol. Chem.130, 219 (1939).

    Google Scholar 

  • Binkley, S. B., R. W. McKee, S. A. Thayer andE. A. Doisy: Structure of vitamin K2. Proc. amer. Soc. Biol.1940.

  • Bray, W. E. andO. R. Kelley: Prothrombin studies, especially in the newborn. Amer. J. clin. Path.10, 154 (1940).

    Google Scholar 

  • Brinkhous, K. M., H. P. Smith andE. D. Warner: Prothrombin deficiency and the bleeding tendency in obstructive jaundice and in biliary fistula. Effect of feeding bile and alfalfa (vitamin K). Amer. J. med. Sci.196, 50 (1938).

    Google Scholar 

  • Burch, E. P. andJ. R. Meade: Treatment of hemorrhagic retinitis with the antihemorrhagic vitamin: Preliminary Report. Minnesota Med.22, 32 (1939).

    Google Scholar 

  • Butt, H. R.: The role of vitamin K in the prevention of hemorrhage arising from diseases of the biliary tract. Surg. Clin. N. Amer. Mayo-Clin.19, 891 (1939).

    Google Scholar 

  • — andA. E. Osterberg: Distribution of vitamin K in biologic material and its probable physiologic significance. J. Nutrit. Suppl.15, 11 (1938).

    Google Scholar 

  • —— andA. M. Snell: (1) The use of vitamin K and bile in treatment of the hemorrhagic diathesis in cases of jaundice. Proc. Staff. Meet. Mayo-Clin.13, 74 (1938).

    Google Scholar 

  • ———: (2) Further observations on the use of vitamin K in the prevention and control of the hemorrhagic diathesis in cases of jaundice. Proc. Staff. Meet. Mayo-Clin.13, 753 (1938).

    Google Scholar 

  • ———: (1) The preoperative and postoperative administration of vitamin K to patients having jaundice. J. amer. med. Assoc.113, 383 (1939).

    Google Scholar 

  • Butt, H. R., A. E. Osterberg andA. M. Snell: (2) Phthiocol; its therapeutic effect in the treatment of hypoprothrombinemia associated with jaundice. A preliminary report. Proc. Staff. Meet. Mayo-Clin.14, 497 (1939).

    Google Scholar 

  • —,A. M. Snell, A. E. Osterberg andJ. L. Bollman: Treatment of hypoprothrombinemia: Use of various synthetic compounds exhibiting antihemorrhagic activity (vitamin K activity). Proc. Staff. Meet., Mayo-Clin.15, 69 (1940).

    Google Scholar 

  • Cheney G.: The intramuscular injection of vitamin K. J. Labor. a. clin. Med.24, 919 (1939).

    Google Scholar 

  • Clark, R. L., Jr.,C. F. Dixon, H. R. Butt andA. M. Snell: Deficiency of prothrombin associated with various intestinal disorders; its treatment with the antihemorrhagic vitamin (vitamin K). Proc. Staff Meet. Mayo-Clin.14, 407 (1939).

    Google Scholar 

  • Cohn, E. T. andC. L. A. Schmidt: Effect of choleic acid of vitamin K on prothrombin levels of bile fistula rats. Proc. Soc. exper. Biol. a. Med.41, 443 (1939).

    Google Scholar 

  • Cole, W. H.: Late advances in diseases of the pancreas. J. Missouri State med. Assoc.36, 353 (1939).

    Google Scholar 

  • Conesa, E. G.: Vitamin K and prothrombin; present status in medicine. Bol. Soc. cubana Pediat.11, 33 (1939).

    Google Scholar 

  • Craven, R.: A sensitive colour reaction for certain quinones. J. chem. Soc. Lond.1931, 1605.

  • Crile, G. Jr.: Recent advances in the therapy of obstructive jaundice. Cleveland Clin. Quart.6, 116 (1939).

    Google Scholar 

  • Dam, H.: Cholesterinstoffwechsel in Hühnereiern und Hühnchen. Biochem. Z.215, 475 (1929).

    Google Scholar 

  • —: Über die Cholesterinsynthese im Tierkörper. Biochem. Z.220, 158 (1930).

    Google Scholar 

  • —: Haemorrhages in chicks reared on artificial diets: a new deficiency disease. Nature (Lond.)133, 909 (1934).

    Google Scholar 

  • —: (1) The antihaemorrhagic vitamin of the chick; occurrence and chemical nature. Nature (Lond.).135, 652 (1935).

    Google Scholar 

  • —: (2) The antihaemorrhagic vitamin of the chick. Biochemic. J.29, 1273 (1935).

    Google Scholar 

  • —: Vitamin K, das fettlösliche antihämorrhagische Vitamin. Angew. Chem.50, 807 (1937).

    Google Scholar 

  • —: Vitamin K. Z. Vitaminforsch.8, 248 (1938/39).

    Google Scholar 

  • —: Vitamin K. Nord Med.3, 2375 (1939).

    Google Scholar 

  • —,A. Geiger, J. Glavind, P. Karrer, W. Karrer, E. Rothschild andH. Salomon: Isolierung des Vitamins K in hochgereinigter Form. Helvet. chim. Acta.22, 310 (1939).

    Google Scholar 

  • — andJ. Glavind, with the co-operation of Mrs.I. Svendsen: (1) Vitamin K in the plant. Biochemic. J.32, 485 (1938).

    Google Scholar 

  • ———: (2) Determination of vitamin K by the curative blood-clotting method. Biochemic. J.32, 1018 (1938).

    Google Scholar 

  • ———: (3) The clotting power of human and mammalian blood in relation to vitamin K. Acta med. scand. (Stockh.)96, 108 (1938).

    Google Scholar 

  • ——: (4) Alimentary exudative diathesis. Nature (Lond.)142, 1077 (1938).

    Google Scholar 

  • Dam, H. andJ. Glavind: (5) Vitamin K in human pathology. Lancet1938 II, 720.

  • ——: (6) Vitamin K I den Menneskelige Patologi. Ugeskr. Laeg. (dän.)100, 248 (1938).

    Google Scholar 

  • ——: Die biologische Aktivität der natürlichen K-Vitamine und einiger verwandter Verbindungen. Helvet. chim. Acta23, 224 (1940).

    Google Scholar 

  • —— with the assistance of Mrs.I. Svendsen: Alimentary K-avitaminosis in rats. Z. Vitaminforsch.9, 71 (1939).

    Google Scholar 

  • ——,L. Lewis, andE. Tage-Hansen with the particular assistance of Mrs.I. Svendsen: Studies on the mode of action of vitamin K. Skand. Arch. Physiol.79, 121 (1938).

    Google Scholar 

  • — andL. Lewis: The chemical concentration of vitamin K. Biochemic J.31, 17 (1937).

    Google Scholar 

  • — andF. Schønheyder: A deficiency disease in chicks resembling scurvy. Biochemic. J.28, 1355 (1934).

    Google Scholar 

  • ——: (1) Vitamin K. Nord. med. Tidskr.12, 1097 (1936).

    Google Scholar 

  • ——: (2) The occurrence and chemical nature of vitamin K. Biochemic J.30, 897 (1936).

    Google Scholar 

  • —— andL. Lewis: The requirement for vitamin K of some different species of animals. Biochemic. J.31, 22 (1937).

    Google Scholar 

  • —— andE. Tage-Hansen: Studies on the mode of action of vitamin K. Biochemic J.30, 1075 (1936).

    Google Scholar 

  • Dam, H., E. Tage-Hansen andP. Plum: (1) K-Avitaminose Hos Spaede Børn Som Aarzag Til Haemorrhagisk Diathese. Ugeskr. Laeg. (dän.)101, 896 (1939).

    Google Scholar 

  • Dam, H., E. Tage-Hansen andP. Plum: (2) Vitamin K lack in normal and sick infants. Lancet1939 II, 1157.

  • Dann, F. P.: Vitamin K assays. Amer. J. Physiol.123, 48 (1938).

    Google Scholar 

  • —: Quantitative biological assay of vitamin K and its application to several quinone compounds. Proc. Soc. exper. Biol. a. Med.42, 663 (1939).

    Google Scholar 

  • Doisy, E. A.: Vitamin K: assay, isolation, constitution and synthetic compounds. Eighth national organic chemistry symposium of the american chemical society. St. Louis, 28.–30. Dez. 1939.

  • —D. W. MacCorquodale, S. A. Thayer, S. B. Binkley andR. W. McKee: The isolation, constitution and synthesis of vitamin K1. Science (N. Y.)90, 407 (1939).

    Google Scholar 

  • —S. B. Binkley, S. A. Thayer andR. W. McKee: Vitamin K. Science (N.Y.)91, 58 (1940).

    Google Scholar 

  • Editorial: (1) Antihemorrhagic factor in foods. J. amer. med. Assoc.108, 1717 (1937).

  • Editorial: (2) Prothrombin deficiency in relation to the bleeding tendency. Ann. int. Med.11, 2284 (1938).

  • Editorial: (3) Vitamin K. Minnesota Med.21, 511 (1938).

  • Editorial: (4) Vitamin K. Brit. med. J.1938, 1060.

  • Editorial: (5) Recent progress with vitamin K. Brit. med. J.1939, 1232.

  • Elliott, M. C., B. Isaacs andA. C. Ivy: Production of “prothrombin deficiency” and response to vitamins A, D and K. Proc. Soc. exper. Biol. a. Med.43, 240 (1940).

    Google Scholar 

  • Emmett, A. D., R. A. Brown andO. Kamm: Comparison of the antihemorrhagic activity of natural and synthetic vitamin K1 with the proposed standard 2-methyl-1,4-naphthoquinone. J. of biol. Chem.132, 467 (1940).

    Google Scholar 

  • —O. Kamm andE. A. Sharp: The vitamin K activity of 4-amino-2-methyl-l-naphthol and 4-amino-3-methyl-l-naphthol. J. of biol. Chem.133, 285 (1940).

    Google Scholar 

  • Engel, R.: Vitamin K deficiency and sprue. Med. Welt13, 120 (1939).

    Google Scholar 

  • Ewing, D. T., J. M. Vandenbelt andO. Kamm: The ultraviolet absorption of vitamins K1, K2 and some related compounds. J. of biol. Chem.131, 345 (1939).

    Google Scholar 

  • Fernholz, E. andS. Ansbacher: Vitamin K activity of synthetic phthiocol. Science (N.Y.)90, 215 (1939).

    Google Scholar 

  • ——, andH. B. MacPhillamy: The vitamin K activity of naphthoquinones. J. amer. chem. Soc.62, 430 (1940).

    Google Scholar 

  • —— andM. L. Moore: On the color reaction for vitamin K. J. amer. chem. Soc.61, 1613 (1939).

    Google Scholar 

  • Fieser, L. F.: (1) Synthesis of 2-methyl-3-phytyl-1,4-naphthoquinone. J. amer. chem. Soc.61, 2559 (1939).

    Google Scholar 

  • —: (2) Identity of synthetic 2-methyl-3-phytyl-1,4-naphthoquinone and vitamin K1. J. amer. chem. Soc.61, 2561 (1939).

    Google Scholar 

  • —: (3) Synthesis of Vitamin K1. J. amer. chem. Soc.61, 3467 (1939).

    Google Scholar 

  • —: The synthesis of vitamin K1. Science (N.Y.)91, 31 (1940).

    Google Scholar 

  • —D. M. Bowen, W. P. Campbell, E. M. Fry andM. D. Gates: Synthesis of antihemorrhagic compounds. J. amer. chem. Soc.61, 1926 (1939).

    Google Scholar 

  • ———: Quinones having vitamin K activity. J. amer. chem. Soc.61, 1925 (1939).

    Google Scholar 

  • —W. P. Campbell andE. M. Fry: Synthesis of quinones related to vitamins K1 and K2. J. amer. chem. Soc.61, 2206 (1939).

    Google Scholar 

  • ——— andM. D., Gates: (1) Synthetic approach to vitamin K1. J. amer. chem. Soc.61, 2559 (1939).

    Google Scholar 

  • ————: (2) Naphthoquinones of the vitamin K1 type of structure. J. amer. chem. Soc.61, 3216 (1939).

    Google Scholar 

  • — andE. M. Fry: Water-soluble antihemorrhagie esters. J. amer. chem. Soc.62, 228 (1940).

    Google Scholar 

  • —M. Tishler andW. L. Sampson: Further compounds having antihemorrhagic activity. J. amer. chem. Soc.62, 996 (1940).

    Google Scholar 

  • — andC. W. Wieghard: Diene synthesis of 2,3-dialkyl-1,4-naphthoquinones related to vitamin K. J. amer. chem. Soc.62, 153 (1940).

    Google Scholar 

  • Flynn, J. E. andE. D. Warner: Prothrombin levels and synthetic vitamin K in obstructive jaundice of rats. Proc. Soc. exper. Biol. a. Med.43, 190 (1940).

    Google Scholar 

  • Foster, R. H. K., J. Lee andU. V. Solmssen: Sodium salt of 2-methyl-1,4-naphthohydroquinone diphosphoric acid ester. J. amer. chem. Soc.62, 453 (1940).

    Google Scholar 

  • Frank, H. A., A. Hurwitz andA. M. Seligman: The treatment of hypoprothrombinemia with synthetic vitamin K1. New England J. Med.221, 975 (1939).

    Google Scholar 

  • Greaves, J. D.: (1) Studies on the vitamin K requirements of the rat. Amer. J. Physiol.125, 429 (1939).

    Google Scholar 

  • —: (2) The nature of the factor which is concerned in loss of blood coagulability of bile-fistula and jaundiced rats. Amer. J. Physiol.125, 423 (1939).

    Google Scholar 

  • — andC. L. A. Schmidt: Nature of the factor concerned in loss of blood coagulability of bile fistula rats. Proc. Soc. exper. Biol. a. Med.37, 43 (1937).

    Google Scholar 

  • Greene, C. H. andR. Holz: Liver and biliary tract; a review for 1938. Arch. int. Med.63, 778 (1939).

    Google Scholar 

  • Halden, W.: Über fettlösliche Vitamine III: Sterine (Steroide), Vitamine D, E, F, K. Fette u. Seifen46, 217 (1939).

    Google Scholar 

  • Hawkins, W. B. andK. M. Brinkhous: Prothrombin deficiency the cause of bleeding in bile fistula dogs. J. of exper. Med.63, 795 (1936).

    Google Scholar 

  • — andG. H. Whipple: Bile fistulas and related abnormalities, bleeding, osteoporosis, cholecystitis and duodenal ulcer. J. of exper. Med.62, 599 (1935).

    Google Scholar 

  • Hellman, L. M. andL. B. Shettles: Factors influencing a plasma prothrombin in the newborn infant. I. Prematurity and vitamin K. Bull. Hopkins Hosp.65, 138 (1939).

    Google Scholar 

  • Holst, W. F. andE. R. Halbrook: A “scurvy-like” disease in chicks. Science (N.Y.)77, 354 (1933).

    Google Scholar 

  • Hult, H.: Fall av sprue behandlat med K-vitamin. Nord. Med.3, 2428 (1939).

    Google Scholar 

  • Illingworth, C. F. W.: (1) Haemorrhage in jaundice. Edinburgh med. J.46, 32 (1939).

    Google Scholar 

  • Illingworth, C. F. W.: (2) Haemorrhage in jaundice. Lancet1939 II, 1031.

  • —: (3) Recent developments in the surgery of obstructive jaundice, with special reference to the risk of haemorrhage. Edinburgh med. J.46, 762 (1939).

    Google Scholar 

  • Kark, R. andE. L. Lozner: Nutritional deficiency of vitamin K in man. Lancet1939 II, 1162.

  • Karrer, P.: Die blauen Alkalisalze des α-Phyllochinons (Vitamin K1) und ähnlicher Verbindungen. Helvet. chim. Acta22, 1146 (1939).

    Google Scholar 

  • — u.A. Epprecht (unter teilweiser Mitarbeit vonK. König): Eine allgemeine Darstellungs-methode für 2-Methyl-3-alkylnaphthochinone. Konstitution und Vitamin K-Wirkung. Helvet. chim. Acta23, 272 (1940).

    Google Scholar 

  • — u.A. Geiger: Vitamin K aus Alfalfa. Helvet. chim. Acta22, 945 (1939).

    Google Scholar 

  • ——A. Rüegger u.H. Salomon: (1) Über die Isolierung des α-Phyllochinons (vitamin K aus Alfalfa) sowie über dessen Entdeckungsgeschichte. Helvet. chim. Acta22, 1464 (1939).

    Google Scholar 

  • ———— (2) Über Nor-α-phyllochinon (Nor-Vitamin K1) und ähnliche Verbindungen. Helvet. chim. Acta22, 1513 (1939).

    Google Scholar 

  • Kato, K.: Micro-prothrombin test with capillary whole blood: A modification ofQuick's quantitative method. Amer. J. clin. Path.10, 147 (1940).

    Google Scholar 

  • — andH. G. Poncher: The prothrombin in the blood of newborn mature and immature infants. J. amer. med. Assoc.114, 749 (1940).

    Google Scholar 

  • Kelley, O. R. andW. E. Bray: Prothrombin time determinations. J. Labor. a. clin. Med.25, 527 (1940).

    Google Scholar 

  • Kline, O. L., J. A. Keeman, C. A. Elvehjem andE. B. Hart: The use of the chick in vitamin B1 and B2 studies. J. of biol. Chem.99, 295 (1932/33).

    Google Scholar 

  • Klose, A. A. andH. J. Almquist: The use of phosphotungstic acid in the preliminary refining of extracts containing vitamin K. J. amer. chem. Soc.61, 532 (1939).

    Google Scholar 

  • ——: Synthesis of vitamin K1. J. of biol. Chem.132, 469 (1940).

    Google Scholar 

  • —— andE. Mecchi: Properties of the antihemorrhagic vitamin (vitamin K). J. of biol. Chem.125, 681 (1938).

    Google Scholar 

  • Koller, F.: Über die klinische Wirksamkeit von Naphthochinonderivaten (Vitamin K-Wirkung). Schweiz. med. Wschr.1939 II, 1159.

  • Koller, F. u.N. Fiechter: Die hämorrhagische Diathese des Neugeborenen und ihre Beziehung zum Vitamin K. Schweiz. med. Wschr.1940, 136.

  • Koller, F. u.F. Wuhrmann: Die Blutgerinnungsstörung bei Stauungsikterus und ihre Behebung durch Vitamin K. Klin. Wschr.1939 I, 1058.

  • Kuhn, R., K. Wallenfels, F. Weygand, T. Moll andL. Hepding: Zur Spezifität des Vitamins K. Naturwiss.27, 518 (1939).

    Google Scholar 

  • Lesser, M. A.: Vitamin K. Drug a. Cosmetic Ind.45, 293 (1939).

    Google Scholar 

  • Lichtman, A. L. andW. H. Chambers: Reduced blood coagulation time by injection of sterol extract of liver. Science (N.Y.)88, 358 (1938).

    Google Scholar 

  • Macfie, M., A. L. Bacharach andM. R. A. Chance: Vitamin K activity of 2-methyl-1,4-naphthoquinone and its use in obstructive jaundice. Brit. med. J.1939, 1220.

  • MacCorquodale, D. W., S. B. Binkley, R. W. McKee, S. A. Thayer andE. A. Doisy: Inactivation of vitamin K by light. Proc. Soc. exper. Biol. a. Med.40, 482 (1939).

    Google Scholar 

  • ——S. A. Thayer andE. A. Doisy: On the constitution of vitamin K1. J. amer. chem. Soc.61, 1928 (1939).

    Google Scholar 

  • —L. C. Cheney, S. B. Binkley, W. F. Holcomb, R. W. McKee, S. A. Thayer andE. A. Doisy: The constitution and synthesis of vitamin K1. J. of biol. Chem.131, 357 (1939).

    Google Scholar 

  • —R. W. McKee, S. B. Binkley, L. C. Cheney, W. F. Holcomb, S. A. Thayer andE. A. Doisy: Identification of vitamin K1 (alfalfa). J. of biol. Chem.130, 433 (1939).

    Google Scholar 

  • Mason, H. C.: Failure of vitamin K excess to heal encephalomalacia of chicks. Proc. Soc. exper. Biol. a. Med.41, 50 (1939).

    Google Scholar 

  • McFarlane, W. D., W. R. Graham, Jr. andF. Richardson: The fatsoluble vitamin requirements of the chick. I. The vitamin A and vitamin D contents of fish meal and meat meal. Biochemic J.25, 358 (1931).

    Google Scholar 

  • —— andG. E. Hall: Studies in protein nutrition of the chick. I. Influence of different protein concentrates on the growth of baby chicks, when fed as the source of protein in various simplified diets. J. Nutrit.4, 331 (1931).

    Google Scholar 

  • McKee, R. W., S. B. Binkley, D. W. MacCorquodale, S. A. Thayer andE. A. Doisy: The isolation of vitamins K1 and K2. J. amer. chem. Soc.61, 1295 (1939).

    Google Scholar 

  • ——S. A. Thayer, D. W. MacCorquodale andE. A. Doisy: The isolation of vitamin K2. J. of biol. Chem.131, 327 (1939).

    Google Scholar 

  • Milliken, L. F.: The use of a new blood coagulant in transurethral prostatic resection. J. d'Urol.42, 75 (1939).

    Google Scholar 

  • Molitor, H. andH. J. Robinson: Oral and parenteral toxicity of vitamin K1, phthiocol and 2-methyl-1,4-naphthoquinone. Proc. Soc. exper. Biol. a. Med.43, 125 (1940).

    Google Scholar 

  • Murphy, R.: Possible avitaminosis K produced in mice by dietary means. Science (N.Y.)89, 203 (1939).

    Google Scholar 

  • Nygaard, K. K.: (1) Profylactic and curative effect of vitamin K in hemorrhagic disease of the newborn (Hypothrombinemia Hemorrhagica Neonatorum). A preliminary report. Acta Obstetr. scand. (Stockh.)19, 361 (1939).

    Google Scholar 

  • —: (2) Vitamin K. Protrombinbestemmelse i blodet. Nord. Med.4, 372 (1939).

    Google Scholar 

  • Olson, K. B. andH. Menzel: The bleeding tendency in obstructive jaundice and its correction by means of vitamin K. Surgery6, 206 (1939).

    Google Scholar 

  • Olson, P. F.: The prothrombin test and the vitamin K treatment for the bleeding tendency in the jaundiced patient. J. Iowa State med. Soc.29, 103 (1939).

    Google Scholar 

  • Osterberg, A. E.: Vitamin K; its distribution and chemical properties; methods of preparation and assay. Proc. Staff. Meet. Mayo-Clin.13, 72 (1938).

    Google Scholar 

  • Owen, C. A., G. R. Hoffman, S. E. Ziffren andH. P. Smith: Blood coagulation during infancy. Proc. Soc. exper. Biol. a Med.41, 181 (1939).

    Google Scholar 

  • Pagniez, P. andA. Varay: Deux Nouvelles Vitamines: La Vitamine P et La Vitamine K. Presse méd.45, 1486 (1937).

    Google Scholar 

  • Phillips, P. H., I. W. Rupel, J. J. Oleson andG. Bohstedt: The effects of an atypical blindness-producing ration upon the vitamin K and C content of calf blood. Proc. amer. Soc. a. Production31, 320 (1938).

    Google Scholar 

  • Quick, A. J.: The coagulation defect in sweet clover disease and in the hemorrhagic chick disease of dietary origin. Amer. J. Physiol.118, 260 (1937).

    Google Scholar 

  • —: The nature of the bleeding in jaundice. J. amer. med. Assoc.110, 1658 (1938).

    Google Scholar 

  • Quick, A. J.: (1) The concentration of prothrombin in infant blood. Proc. amer. Soc. Biol.1939.—J. of biol. Chem.128, LXXX (1939).

  • —: (2) Determination of prothrombin. Proc. Soc. exper. Biol. a. Med.42, 788 (1939).

    Google Scholar 

  • —: (1) The clinical applications of the hippuric acid and the prothrombin tests. Amer. J. clin. Path.10, 222 (1940).

    Google Scholar 

  • Quick, A. J.: (2) Assay method for vitamin K. Proc. amer. Soc. Biol.1940.

  • — andA. M. Grossmann: (1) Concentration of prothrombin in blood of babies 3 to 7 days old. Proc. Soc. exper. Biol. a Med.40, 647 (1939).

    Google Scholar 

  • ——: (2) Prothrombin concentration in newborn. Proc. Soc. exper. Biol. a. Med.41, 227 (1939).

    Google Scholar 

  • —M. Stanley-Brown, andF. W. Bancroft: A study of the coagulation defect in hemophilia and in jaundice. Amer. J. med. Sci.190, 501 (1935).

    Google Scholar 

  • Ravdin, I. S.: (1) Surgical diseases of the extrahepatic bile ducts. New England J. Med.220, 326 (1939).

    Google Scholar 

  • —: (2) Surgical Therapeusis. Ann. Surg.109, 325 (1939).

    Google Scholar 

  • Rhoads, J. E.: The relation of vitamin K to the hemorrhagic tendency in obstructive jaundice, with a report on cerophyl as a source of vitamin K. Surgery5, 794 (1939).

    Google Scholar 

  • — andM. T. Fliegelman: The use of 2-methyl-1,4-naphthoquinone (a synthetic vitamin K substitute). J. amer. med. Assoc.114, 400 (1940).

    Google Scholar 

  • Riegel, B., C. E. Schweitzer andP. G. Smith: The physicochemical concentration of vitamin K. J. of biol. Chem.129, 495 (1939).

    Google Scholar 

  • —P. G. Smith andC. E. Schweitzer: The oxidation-reduction potential of vitamin K1. J. amer. chem. Soc.62, 992 (1940).

    Google Scholar 

  • Scanlon, G. H., K. M. Brinkhous, E. D. Warner, H. P. Smith andJ. E. Flynn: Plasma prothrombin and the bleeding tendency. J. amer. med. Assoc.112, 1898 (1939).

    Google Scholar 

  • Schmidt, C. L. A.: Vitamin K: A new therapeutic agent. Pacific Coast Med.5, 7 (1938).

    Google Scholar 

  • Schønheyder, F.: The antihaemorrhagic vitamin of the chick, measurement and biological action. Nature (Lond.)135, 653 (1935).

    Google Scholar 

  • —: The quantitative determination of Vitamin K. I. Biochemic J.30, 890 (1936).

    Google Scholar 

  • —: Prothrombin in chickens. Amer. J. Physiol.123, 349 (1938).

    Google Scholar 

  • Sjögren, B.: Die Vitamin K-Wirkung einiger Naphthochinone und Naphthochinonderivate. Hoppe-Seylers Z.262, 1 (1939).

    Google Scholar 

  • Smith, W. K.: Failure of alfalfa to prevent the hemorrhagic sweet-clover disease. Science (N.Y.)87, 419 (1938).

    Google Scholar 

  • —: The alleged protective action of alfalfa against the hemorrhagic sweet-clover disease. J. agricult Res.59, 211 (1939).

    Google Scholar 

  • Smith, H. P., E. D. Warner andK. M. Brinkhous: Prothrombin deficiency and the bleeding tendency in liver injury (chloroform intoxication). J. of exper. Med.66, 801 (1937).

    Google Scholar 

  • ———, andW. H. Seegers: Bleeding tendency and prothrombin deficiency in biliary fistula dogs: effect of feeding bile and vitamin K. J. of exper. Med.67, 911 (1938).

    Google Scholar 

  • —S. E. Ziffren, C. A. Owen andG. R. Hoffman: Clinical and experimental studies on vitamin K. J. amer. med. Assoc.113, 380 (1939).

    Google Scholar 

  • ————: andJ. E. Flynn: The jaundiced bleeder: control of hemorrhage through vitamin K therapy. J. Iowa State med. Soc.29, 377 (1939).

    Google Scholar 

  • Snell, A. M.: The treatment of liver disease. Ann. internat. Med.12, 592 (1938).

    Google Scholar 

  • —: (1) Vitamin K: its properties, distribution and clinical importance. A preliminary report. J. amer. med. Assoc.112, 1457 (1939).

    Google Scholar 

  • —: (2) Complications and sequelae of obstructive jaundice with special reference to the hemorrhagic diathesis. Mississippi Doctor17, 1 (1939).

    Google Scholar 

  • — andH. R. Butt: Preliminary report on vitamin K. II. J. amer. med. Assoc.113, 2056 (1939).

    Google Scholar 

  • —— andA. E. Osterberg: Treatment of the hemorrhagic tendency in jaundice; with special reference to vitamin K. Amer. J. digest. Dis. a Nutrit.5, 590 (1938).

    Google Scholar 

  • Stewart, J. D.: Prothrombin deficiency and the effects of vitamin K in obstructive jaundice and biliary fistula. Ann. Surg.109, 588 (1939).

    Google Scholar 

  • — andG. M. Rourke: (1) Prothrombia and vitamin K therapy. New England J. Med.221, 403 (1939).

    Google Scholar 

  • Stewart, J. D., G. M. Rourke: (2) Control of prothrombin deficiency in obstructive jaundice by use of vitamin K. J. amer. med. Assoc.113, 2223 (1939).

    Google Scholar 

  • Supniewsky, J. W., J. Hano andN. E. Teschner: (On the toxicity of phthiocol.) Bull internat. acad. pelon. Sci.33 (1936).

  • Tage-Hansen, E.: Summary of some clinical studies on vitamin K. J. amer. med. Assoc.113, 1875 (1939).

    Google Scholar 

  • Thayer, S. A., S. B. Binkley, D. W. MacCorquodale, E. A. Doisy, A. D. Emmett, R. A. Brown andO. D. Bird: Vitamin K potencies of synthetic compounds. J. amer chem. Soc.61, 2563 (1939).

    Google Scholar 

  • —L. C. Cheney, S. B. Binkley, D. W. MacCorquodale andE. A. Doisy: Vitamin K activity of some quinones. J. amer. chem. Soc.61, 1932 (1939).

    Google Scholar 

  • —D. W. MacCorquodale, S. B. Binkley andE. A. Doisy: The isolation of a crystalline compound with vitamin K activity. Science (N.Y.)88, 243 (1938).

    Google Scholar 

  • —,R. W. McKee, S. B. Binkley, D. W. MacCorquodale andE. A. Doisy: (1) Assay of vitamin K concentrates. Proc. Soc. exper. Biol. a. Med.40, 478 (1939).

    Google Scholar 

  • —————: (2) The assay of vitamins K1 and K2 Proc. Soc. exper. Biol. a. Med.41, 194 (1939).

    Google Scholar 

  • ——D. W. MacCorquodale andE. A. Doisy: Recovery from the anemia caused by a diet deficient in vitamin K. Proc. Soc. exper. Biol. a. Med.37, 417 (1937).

    Google Scholar 

  • Tidrick, R. T., F. T. Joyce andH. P. Smith: Vitamin K deficiency and prothrombin levels. Proc. Soc. exper. Biol. a. Med.42, 853 (1939).

    Google Scholar 

  • Tishler, M. andW. L. Sampson: Antihemorrhagic activity of simple compounds. J. amer. chem. Soc.61, 2563 (1939).

    Google Scholar 

  • Tomaszewski, W. u.C. Engel: Vitamin A und C bei Kücken während der Vitamin K-Avitaminose. Z. Vitaminforsch.9, 238 (1939).

    Google Scholar 

  • Townsend, S. R. andE. S. Mills: The use of vitamin K and bile salts in the prevention and control of the haemorrhagic diathesis in obstructive jaundice. Canad. med. Assoc. J.41, 111 (1939).

    Google Scholar 

  • Waddell, W. W. andD. Guerry III: Effect of vitamin K on the clotting time of the prothrombin and the blood with special reference to unnatural bleeding of the newly born. J. amer. med. Assoc.112, 2259 (1939).

    Google Scholar 

  • ——W. E. Bray andO. R. Kelley: Possible effects of vitamin K on prothrombin and clotting time in newly-born infants. Proc. Soc. exper. Biol. a. Med.40, 432 (1939).

    Google Scholar 

  • Warner, E. D., K. M. Brinkhous andH. P. Smith: A quantitative study of blood clotting: prothrombin fluctuations under experimental conditions. Amer. J. Physiol.114, 667 (1936).

    Google Scholar 

  • ———: (1) Bleeding tendency of obstructive jaundice: prothrombin deficiency and dietary factors. Proc. Soc. exper. Biol. a. Med.37, 628 (1938).

    Google Scholar 

  • ———: (2) Prothrombin deficiency and the bleeding tendency in obstructive jaundice and in biliary fistula. Amer. J. med. Sci.196, 50 (1938).

    Google Scholar 

  • Wigodsky, H. S. andA. C. Ivy: Assay of a vitamin K preparation for vitamin D. Proc. Soc. exper. Biol. a. Med.38, 785 (1938).

    Google Scholar 

  • Wilbur, D. L. andA. M. Snell: Deficiency states associated with gastro-intestinal disease. Amer. J. digest. Dis. a. Nutrit.4, 720 (1938).

    Google Scholar 

  • Wiles, H. O. andS. Maurer: The antihemorrhagic factor of mammalian liver fat. Science (N.Y.)89, 293 (1939).

    Google Scholar 

  • Ziffren, S. E., C. A. Owen, G. R. Hoffman andH. P. Smith: Control of vitamin K therapy; compensatory mechanisms at low prothrombin levels. Proc. Soc. exper. Biol. a. Med.40, 595 (1939).

    Google Scholar 

  • Zuckerman, C., B. Kogut, M. Jacobi, andJ. Y. Cohen: Studies in human biliary physiology. III. The effect of bile and vitamin K on experimentally produced hemorrhagic diathesis in a human with a total external biliary fistula. Amer. J. digest. Dis. a. Nutrit.6, 332 (1939).

    Google Scholar 

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    Byron Riegel

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Riegel, B. Vitamins K. Ergebnisse der Physiologie und exper. Pharmakologie 43, 133–173 (1940). https://doi.org/10.1007/BF02320663

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