Summary
Binding constants between adamantane carboxylic acids and β-cyclodextrin derivatives were determined by capillary electrophoresis (CE) using indirect detection. In this procedure, a mixture of adamantane derivative and non-interacting anionic standards, is injected and analysis of the electrophoretic mobility, relative to the noninteracting anionic standards, as a function of the concentration of cyclodextrin, yields values for their binding constants to the adamantane derivative. The usefulness of the method for quantification of binding constants is demonstrated.
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Kwak, E.S., Gomez, F.A. Determination of the binding of β-cyclodextrin derivatives to adamantane carboxylic acids using capillary electrophoresis. Chromatographia 43, 659–662 (1996). https://doi.org/10.1007/BF02292984
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DOI: https://doi.org/10.1007/BF02292984